| Publication Information (EuropePMC) | |
| Title | Phenotype integration improves power and preserves specificity in biobank-based genetic studies of MDD |
| doi | 10.1101/2022.08.15.503980 |
| Publication Date | Aug. 15, 2022 |
| Journal | bioRxiv Preprint |
| Author(s) | Dahl A, Thompson M, An U, Krebs M, Appadurai V, Border R, Bacanu S, Werge T, Flint J, Schork AJ, Sankararaman S, Kendler K, Cai N. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS003577 (AutoImpOnly.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 5,776,312 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003577/ScoringFiles/PGS003577.txt.gz | |
| PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 4,861,398 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003583/ScoringFiles/PGS003583.txt.gz | |
| PGS003584 (SoftImpAll.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 5,776,312 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003584/ScoringFiles/PGS003584.txt.gz | |
| PGS003585 (SoftImpOnly.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 5,776,312 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003585/ScoringFiles/PGS003585.txt.gz | |
| PGS003579 (MTAG.AllDep.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 4,786,322 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003579/ScoringFiles/PGS003579.txt.gz | |
| PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 4,786,322 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003580/ScoringFiles/PGS003580.txt.gz | |
| PGS003581 (MTAG.Envs.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 4,861,398 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003581/ScoringFiles/PGS003581.txt.gz | |
| PGS003576 (AutoImpAll.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 5,776,312 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003576/ScoringFiles/PGS003576.txt.gz | |
| PGS003578 (MTAG.All.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 4,786,322 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003578/ScoringFiles/PGS003578.txt.gz | |
| PGS003582 (MTAG.FamHist.LifetimeMDD) |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Major Depressive Disorder (Lifetime) | major depressive disorder | 4,861,398 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003582/ScoringFiles/PGS003582.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM018180 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00898 | PCs 1-10 | — |
| PPM018181 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00726 | PCs 1-10 | — |
| PPM018182 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0044 | PCs 1-10 | — |
| PPM018183 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00842 | PCs 1-10 | — |
| PPM018184 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00537 | PCs 1-10 | — |
| PPM018185 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0207 | PCs 1-10 | — |
| PPM018187 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00508 | PCs 1-20 | — |
| PPM018188 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0071 | PCs 1-20 | — |
| PPM018189 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01722 | PCs 1-20 | — |
| PPM018190 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01492 | PCs 1-10 | — |
| PPM018191 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00395 | PCs 1-10 | — |
| PPM018192 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00491 | PCs 1-10 | — |
| PPM018193 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00837 | PCs 1-10 | — |
| PPM018194 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00546 | PCs 1-10 | — |
| PPM018196 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0121 | PCs 1-10 | — |
| PPM018197 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01598 | PCs 1-20 | — |
| PPM018198 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.02548 | PCs 1-20 | — |
| PPM018199 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01284 | PCs 1-20 | — |
| PPM018200 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00727 | PCs 1-10 | — |
| PPM018201 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01033 | PCs 1-10 | — |
| PPM018202 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00658 | PCs 1-10 | — |
| PPM018204 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00491 | PCs 1-10 | — |
| PPM018205 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0241 | PCs 1-10 | — |
| PPM018206 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0181 | PCs 1-10 | — |
| PPM018207 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01668 | PCs 1-20 | — |
| PPM018208 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.02062 | PCs 1-20 | — |
| PPM018209 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01847 | PCs 1-20 | — |
| PPM018210 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01013 | PCs 1-10 | — |
| PPM018211 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00938 | PCs 1-10 | — |
| PPM018212 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00505 | PCs 1-10 | — |
| PPM018213 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00482 | PCs 1-10 | — |
| PPM018214 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00405 | PCs 1-10 | — |
| PPM018215 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0182 | PCs 1-10 | — |
| PPM018216 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0141 | PCs 1-10 | — |
| PPM018217 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00953 | PCs 1-20 | — |
| PPM018219 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01454 | PCs 1-20 | — |
| PPM018220 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00551 | PCs 1-10 | — |
| PPM018221 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01906 | PCs 1-10 | — |
| PPM018222 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00363 | PCs 1-10 | — |
| PPM018223 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00962 | PCs 1-10 | — |
| PPM018224 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00957 | PCs 1-10 | — |
| PPM018226 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0145 | PCs 1-10 | — |
| PPM018227 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01562 | PCs 1-20 | — |
| PPM018228 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01608 | PCs 1-20 | — |
| PPM018229 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01652 | PCs 1-20 | — |
| PPM018230 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00169 | PCs 1-10 | — |
| PPM018231 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00598 | PCs 1-10 | — |
| PPM018232 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00234 | PCs 1-10 | — |
| PPM018233 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00581 | PCs 1-10 | — |
| PPM018235 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0182 | PCs 1-10 | — |
| PPM018236 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0147 | PCs 1-10 | — |
| PPM018237 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01186 | PCs 1-20 | — |
| PPM018238 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01336 | PCs 1-20 | — |
| PPM018239 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01224 | PCs 1-20 | — |
| PPM018240 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00305 | PCs 1-10 | — |
| PPM018241 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01232 | PCs 1-10 | — |
| PPM018242 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00193 | PCs 1-10 | — |
| PPM018244 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00819 | PCs 1-10 | — |
| PPM018245 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0104 | PCs 1-10 | — |
| PPM018246 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0064 | PCs 1-10 | — |
| PPM018247 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00441 | PCs 1-20 | — |
| PPM018248 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01656 | PCs 1-20 | — |
| PPM018249 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01091 | PCs 1-20 | — |
| PPM018250 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00955 | PCs 1-10 | — |
| PPM018251 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.02257 | PCs 1-10 | — |
| PPM018253 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0115 | PCs 1-10 | — |
| PPM018254 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01013 | PCs 1-10 | — |
| PPM018255 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0204 | PCs 1-10 | — |
| PPM018256 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0155 | PCs 1-10 | — |
| PPM018257 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01754 | PCs 1-20 | — |
| PPM018258 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01951 | PCs 1-20 | — |
| PPM018259 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01771 | PCs 1-20 | — |
| PPM018260 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00134 | PCs 1-10 | — |
| PPM018262 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00539 | PCs 1-10 | — |
| PPM018263 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01207 | PCs 1-10 | — |
| PPM018264 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00827 | PCs 1-10 | — |
| PPM018265 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0254 | PCs 1-10 | — |
| PPM018266 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0207 | PCs 1-10 | — |
| PPM018267 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.02512 | PCs 1-20 | — |
| PPM018268 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01435 | PCs 1-20 | — |
| PPM018269 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.02075 | PCs 1-20 | — |
| PPM018271 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01 | PCs 1-10 | — |
| PPM018272 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0048 | PCs 1-10 | — |
| PPM018273 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01087 | PCs 1-10 | — |
| PPM018274 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00943 | PCs 1-10 | — |
| PPM018275 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0257 | PCs 1-10 | — |
| PPM018276 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0199 | PCs 1-10 | — |
| PPM018277 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010951| African Ancestry| 687 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.02024 | PCs 1-20 | — |
| PPM018278 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.02182 | PCs 1-20 | — |
| PPM018203 | PGS003576 (AutoImpAll.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01563 | PCs 1-10 | — |
| PPM018186 | PGS003584 (SoftImpAll.LifetimeMDD) |
PSS010955| European Ancestry| 23,351 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.016 | PCs 1-10 | — |
| PPM018195 | PGS003585 (SoftImpOnly.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0176 | PCs 1-10 | — |
| PPM018218 | PGS003577 (AutoImpOnly.LifetimeMDD) |
PSS010952| Additional Asian Ancestries| 334 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01605 | PCs 1-20 | — |
| PPM018225 | PGS003583 (MTAG.GPpsy.LifetimeMDD) |
PSS010954| European Ancestry| 42,250 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0198 | PCs 1-10 | — |
| PPM018234 | PGS003581 (MTAG.Envs.LifetimeMDD) |
PSS010950| East Asian Ancestry| 10,502 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00336 | PCs 1-10 | — |
| PPM018243 | PGS003582 (MTAG.FamHist.LifetimeMDD) |
PSS010949| Hispanic or Latin American Ancestry| 2,454 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00709 | PCs 1-10 | — |
| PPM018252 | PGS003579 (MTAG.AllDep.LifetimeMDD) |
PSS010948| European Ancestry| 14,388 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.00435 | PCs 1-10 | — |
| PPM018261 | PGS003580 (MTAG.AllDepEnvs.LifetimeMDD) |
PSS010947| Additional Asian Ancestries| 1,996 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0156 | PCs 1-10 | — |
| PPM018270 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010946| African Ancestry| 1,158 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.0038 | PCs 1-10 | — |
| PPM018279 | PGS003578 (MTAG.All.LifetimeMDD) |
PSS010953| European Ancestry| 10,193 individuals |
PGP000461 | Dahl A et al. bioRxiv (2022) |Pre |
Reported Trait: Major depressive disorder | — | — | R²: 0.01995 | PCs 1-20 | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS010946 | — | — | [
|
Range = [18.0, 86.0] years | African unspecified (Black) |
— | UCLA | — |
| PSS010947 | — | — | [
|
Range = [18.0, 86.0] years | Asian unspecified (Asian) |
— | UCLA | — |
| PSS010948 | — | — | [
|
Range = [18.0, 86.0] years | European | — | UCLA | — |
| PSS010949 | — | — | [
|
Range = [18.0, 86.0] years | Hispanic or Latin American (Latino) |
— | UCLA | — |
| PSS010950 | — | — | [
|
Range = [30.0, 60.0] years | East Asian (Han Chinese) |
— | CONVERGE | — |
| PSS010951 | — | — | [
|
Range = [37.0, 74.0] years | African unspecified (African) |
— | UKB | — |
| PSS010952 | — | — | [
|
Range = [37.0, 74.0] years | Asian unspecified (Asian) |
— | UKB | — |
| PSS010953 | — | — | [
|
Range = [37.0, 74.0] years | European | — | UKB | — |
| PSS010954 | — | — | [
|
Range = [8.0, 32.0] years | European (Danish) |
— | iPSYCH | — |
| PSS010955 | — | — | [
|
Range = [8.0, 35.0] years | European (Danish) |
— | iPSYCH | — |