PGS Publication: PGP000471

Publication Information (EuropePMC)
Title Genetic Associations Between Smoking- and Glaucoma-Related Traits.
PubMed ID 36786746(Europe PMC)
doi 10.1167/tvst.12.2.20
Publication Date Feb. 1, 2023
Journal Transl Vis Sci Technol
Author(s) Tran JH, Stuart KV, de Vries V, Vergroesen JE, Cousins CC, Hysi PG, Do R, Rocheleau G, Kang JH, Wiggs JL, MacGregor S, Khawaja AP, Mackey DA, Klaver CCW, Ramdas WD, Pasquale LR, UK Biobank Eye and Vision Consortium, and for the International Glaucoma Genetics Consortium.
Released in PGS Catalog: June 22, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003747
(GRS341_SI)
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Smoking initiation smoking initiation 341
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003747/ScoringFiles/PGS003747.txt.gz
PGS003748
(GRS46_CPD)
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Cigarettes smoked per day cigarettes per day measurement 46
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003748/ScoringFiles/PGS003748.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018503 PGS003747
(GRS341_SI)
 PSS010997|
Ancestry Not Reported|
14,921 individuals
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Reported Trait: Any history of smoking OR: 1.2 [1.15, 1.25] — — — —
PPM018504 PGS003747
(GRS341_SI)
 PSS010997|
Ancestry Not Reported|
14,921 individuals
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Reported Trait: Cigarettes per day OR: 0.45 [0.19, 0.7] — — — —
PPM018505 PGS003748
(GRS46_CPD)
 PSS010997|
Ancestry Not Reported|
14,921 individuals
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Reported Trait: Cigarettes per day OR: 0.68 [0.43, 0.93] — — — —
PPM018506 PGS003747
(GRS341_SI)
 PSS010997|
Ancestry Not Reported|
14,921 individuals
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Reported Trait: Open-angle glaucoma OR: 0.84 [0.73, 0.98] — — — —
PPM018507 PGS003747
(GRS341_SI)
 PSS010997|
Ancestry Not Reported|
14,921 individuals
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Reported Trait: Intraocular pressure OR: -0.09 [-0.17, -0.01] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010997 — — 14,921 individuals,
40.9 % Male samples
 Mean = 66.1 years Not reported — RS —