PGS Publication: PGP000480

Publication Information (EuropePMC)
Title Identification of specific susceptibility loci for the early-onset colorectal cancer.
PubMed ID 36869385(Europe PMC)
doi 10.1186/s13073-023-01163-w
Publication Date March 3, 2023
Journal Genome Med
Author(s) Wang H, Cai Y, Jin M, Huang CQ, Ning C, Niu S, Fan L, Li B, Zhang M, Lu Z, Dong X, Luo Z, Zhong R, Li H, Zhu Y, Miao X, Yang X, Chang J, Li N, Tian J.
Released in PGS Catalog: Aug. 4, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003760
(PRS49_EOCRC)
 PGP000480 |
Wang H et al. Genome Med (2023)
 Early onset colorectal cancer colorectal cancer 49
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003760/ScoringFiles/PGS003760.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018549 PGS003760
(PRS49_EOCRC)
 PSS011018|
Multi-ancestry (including European)|
25,150 individuals
 PGP000480 |
Wang H et al. Genome Med (2023)
 Reported Trait: Early onset colorectal cancer — — Odds ratio (OR, Quartile 4 vs Quartile 1): 1.64 [1.32, 2.03] Sex, ethnicity, drinking frequency, smoke status, and family history —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011018 — —
[
  • 690 cases
  • , 23,244 controls
]
 — European — UKB —
PSS011018 — —
[
  • 4 cases
  • , 125 controls
]
 — European, African American or Afro-Caribbean, African unspecified, Asian unspecified, NR European and African Caribbean, European and Black African, European and Asian, NR UKB —
PSS011018 — —
[
  • 12 cases
  • , 486 controls
]
 — Asian unspecified — UKB —
PSS011018 — —
[
  • 12 cases
  • , 370 controls
]
 — African unspecified — UKB —
PSS011018 — —
[
  • 5 cases
  • , 202 controls
]
 — Not reported — UKB —