PGS Publication: PGP000485

Publication Information (EuropePMC)
Title Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework.
PubMed ID 36895094(Europe PMC)
doi 10.1002/alz.12980
Publication Date March 9, 2023
Journal Alzheimers Dement
Author(s) Mourtzi N, Charisis S, Tsapanou A, Ntanasi E, Hatzimanolis A, Ramirez A, Heilmann-Heimbach S, Grenier-Boley B, Lambert JC, Yannakoulia M, Kosmidis M, Dardiotis E, Hadjigeorgiou G, Sakka P, Georgakis M, Yaakov S, Scarmeas N.
Released in PGS Catalog: Aug. 4, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003762
(PRS57_amyloid)
 PGP000485 |
Mourtzi N et al. Alzheimers Dement (2023)
 Amyloid beta 42 beta-amyloid 1-42 measurement 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003762/ScoringFiles/PGS003762.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018562 PGS003762
(PRS57_amyloid)
 PSS011025|
Ancestry Not Reported|
618 individuals
 PGP000485 |
Mourtzi N et al. Alzheimers Dement (2023)
 Reported Trait: Incidence of Alzheimer's disease/amnestic mild cognitive impairment with high cognitive reserve HR: 0.408 [0.215, 0.775] — — age, sex, PC1, PC2, APOE e4 —
PPM018561 PGS003762
(PRS57_amyloid)
 PSS011025|
Ancestry Not Reported|
618 individuals
 PGP000485 |
Mourtzi N et al. Alzheimers Dement (2023)
 Reported Trait: Incidence of Alzheimer's disease/amnestic mild cognitive impairment HR: 1.339 [1.072, 1.672] — — CR, age, sex, PC1, PC2, APOE e4 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011025 — Mean = 2.92 years 618 individuals,
41.6 % Male samples
 Mean = 73.37 years
Sd = 4.96 years		 Not reported — HELIAD Hellenic Longitudinal Investigation of Aging and Diet