PGS Publication: PGP000497

Publication Information (EuropePMC)
Title Identifying the potential causal role of insomnia symptoms on 11,409 health-related outcomes: a phenome-wide Mendelian randomisation analysis in UK Biobank.
PubMed ID 37013595(Europe PMC)
doi 10.1186/s12916-023-02832-8
Publication Date April 3, 2023
Journal BMC Med
Author(s) Gibson MJ, Lawlor DA, Millard LAC.
Released in PGS Catalog: Sept. 1, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003859
(GRS129_insomnia)
 PGP000497 |
Gibson MJ et al. BMC Med (2023)
 Insomnia insomnia measurement 129
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003859/ScoringFiles/PGS003859.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018713 PGS003859
(GRS129_insomnia)
 PSS011077|
European Ancestry|
336,975 individuals
 PGP000497 |
Gibson MJ et al. BMC Med (2023)
 Reported Trait: Insomnia symptoms (usually vs never/rarely/sometimes having trouble falling or staying asleep) OR: 1.08 [1.07, 1.09] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011077 — — 336,975 individuals,
46.0 % Male samples
 — European — UKB —