PGS Publication: PGP000505

Publication Information (EuropePMC)
Title Associations of serum uric acid levels with liver disease-related morbidity and mortality: A prospective cohort study of the UK Biobank.
PubMed ID 36938749(Europe PMC)
doi 10.1111/liv.15564
Publication Date March 29, 2023
Journal Liver Int
Author(s) Liu Z, Huang H, Xie J, Xu C.
Released in PGS Catalog: Oct. 17, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000872
(PRS-5)
 PGP000215 |
Bianco C et al. J Hepatol (2020)
 Non-alcoholic fatty liver disease non-alcoholic fatty liver disease 5
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000872/ScoringFiles/PGS000872.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019102 PGS000872
(PRS-5)
 PSS011182|
European Ancestry|
381,825 individuals
 PGP000505 |
Liu Z et al. Liver Int (2023)
|Ext.		 Reported Trait: Non-alcoholic fatty liver disease — — p-value (inferior to): 0.001 age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR —
PPM019103 PGS000872
(PRS-5)
 PSS011182|
European Ancestry|
381,825 individuals
 PGP000505 |
Liu Z et al. Liver Int (2023)
|Ext.		 Reported Trait: Severe liver disease — — p-value (inferior to): 0.001 age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR —
PPM019104 PGS000872
(PRS-5)
 PSS011182|
European Ancestry|
381,825 individuals
 PGP000505 |
Liu Z et al. Liver Int (2023)
|Ext.		 Reported Trait: Serum uric acid levels x PRS interaction for liver disease HR: 1.03 [1.01, 1.05] — — age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR —
PPM019105 PGS000872
(PRS-5)
 PSS011182|
European Ancestry|
381,825 individuals
 PGP000505 |
Liu Z et al. Liver Int (2023)
|Ext.		 Reported Trait: Serum uric acid levels x PRS interaction for severe liver disease HR: 1.06 [1.03, 1.1] — — age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR —
PPM019101 PGS000872
(PRS-5)
 PSS011182|
European Ancestry|
381,825 individuals
 PGP000505 |
Liu Z et al. Liver Int (2023)
|Ext.		 Reported Trait: Liver disease — — p-value (inferior to): 0.001 age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011182 — — 381,825 individuals — European — UKB —