PGS Publication: PGP000508

Publication Information (EuropePMC)
Title Development and validation of a simple prostate cancer risk prediction model based on age, family history, and polygenic risk.
PubMed ID 37062910(Europe PMC)
doi 10.1002/pros.24537
Publication Date April 16, 2023
Journal Prostate
Author(s) Dite GS, Spaeth E, Murphy NM, Allman R.
Released in PGS Catalog: Oct. 17, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000662
(GRS.PCa.269)
 PGP000122 |
Conti DV et al. Nat Genet (2021)
 Prostate cancer prostate carcinoma 269
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000662/ScoringFiles/PGS000662.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019114 PGS000662
(GRS.PCa.269)
 PSS011185|
European Ancestry|
189,338 individuals
 PGP000508 |
Dite GS et al. Prostate (2023)
|Ext.		 Reported Trait: Prostate cancer — — Hazard Ratio (HR per change in transformed PRS): 5.846 [4.264, 8.013] age, family history Effect sized based on ln(PRS)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011185 — —
[
  • 8,996 cases
  • , 180,342 controls
]
,
100.0 % Male samples
 Mean = 62.1 years
Sd = 5.5 years		 European — UKB —