PGS Publication: PGP000527

Publication Information (EuropePMC)
Title Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease.
PubMed ID 36814324(Europe PMC)
doi 10.1186/s13195-023-01184-y
Publication Date Feb. 22, 2023
Journal Alzheimers Res Ther
Author(s) Green RE, Lord J, Scelsi MA, Xu J, Wong A, Naomi-James S, Handy A, Gilchrist L, Williams DM, Parker TD, Lane CA, Malone IB, Cash DM, Sudre CH, Coath W, Thomas DL, Keuss S, Dobson R, Legido-Quigley C, Fox NC, Schott JM, Richards M, Proitsi P, Insight 46 study team.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004228
(ad_apoe_0.1_pgs)
 PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
 Alzheimer's disease Alzheimer disease 8,863
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004228/ScoringFiles/PGS004228.txt.gz
PGS004229
(ad_noapoe_0.1_pgs)
 PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
 Alzheimer's disease Alzheimer disease 8,858
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004229/ScoringFiles/PGS004229.txt.gz
PGS004227
(ad_apoe_gw_pgs)
 PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
 Alzheimer's disease Alzheimer disease 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004227/ScoringFiles/PGS004227.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020218 PGS004227
(ad_apoe_gw_pgs)
 PSS011307|
Ancestry Not Reported|
1,638 individuals
 PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
 Reported Trait: Alzheimer's disease biomarker (1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1) β: -0.06101 [-0.108607308, -0.013407489] — — — —
PPM020223 PGS004229
(ad_noapoe_0.1_pgs)
 PSS011307|
Ancestry Not Reported|
1,638 individuals
 PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
 Reported Trait: Alzheimer's disease biomarker (linolenate (18:3n3 or 3n6)) β: -0.05431 [-0.103025695, -0.005590157] — — — —
PPM020220 PGS004227
(ad_apoe_gw_pgs)
 PSS011307|
Ancestry Not Reported|
1,638 individuals
 PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
 Reported Trait: Alzheimer's disease biomarker (palmitoyl-myristoyl-glycerol (16:0/14:0) [1]) β: -0.0502 [-0.098164771, -0.002232543] — — — —
PPM020222 PGS004229
(ad_noapoe_0.1_pgs)
 PSS011307|
Ancestry Not Reported|
1,638 individuals
 PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
 Reported Trait: Alzheimer's disease biomarker (docosapentaenoate (DPA; 22:5n3)) β: -0.07733 [-0.125825807, -0.028839878] — — — —
PPM020219 PGS004227
(ad_apoe_gw_pgs)
 PSS011307|
Ancestry Not Reported|
1,638 individuals
 PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
 Reported Trait: Alzheimer's disease biomarker (palmitoyl-palmitoyl-glycerol (16:0/16:0) [1]) β: -0.0559 [-0.103719741, -0.008088708] — — — —
PPM020221 PGS004228
(ad_apoe_0.1_pgs)
 PSS011307|
Ancestry Not Reported|
1,638 individuals
 PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
 Reported Trait: Alzheimer's disease biomarker (docosapentaenoate (DPA; 22:5n3)) β: -0.05808 [-0.106496039, -0.009669554] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011307 — — 1,638 individuals,
49.6 % Male samples
 — Not reported — NSHD Outcomes tested were metabolite levels generated by Metabolon Inc, and metabolite modules generated using this data. All outcome (metabolite) data were collected at the 60-64 wave of the NSHD.