PGS Publication: PGP000530

Publication Information (EuropePMC)
Title Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes.
PubMed ID 36175048(Europe PMC)
doi 10.1016/j.jacc.2022.07.027
Publication Date Oct. 1, 2022
Journal J Am Coll Cardiol
Author(s) Lacaze P, Bakshi A, Riaz M, Polekhina G, Owen A, Bhatia HS, Natarajan P, Wolfe R, Beilin L, Nicholls SJ, Watts GF, McNeil JJ, Tonkin AM, Tsimikas S.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000667
(LPA_GRS43)
 PGP000127 |
Trinder M et al. JAMA Cardiol (2020)
 Lipoprotein A lipoprotein A measurement 43
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000667/ScoringFiles/PGS000667.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020250 PGS000667
(LPA_GRS43)
 PSS011311|
European Ancestry|
12,815 individuals
 PGP000530 |
Lacaze P et al. J Am Coll Cardiol (2022)
|Ext.		 Reported Trait: Incidence of major adverse cardiovascular events HR: 1.14 [1.05, 1.24] — — — —
PPM020251 PGS000667
(LPA_GRS43)
 PSS011311|
European Ancestry|
12,815 individuals
 PGP000530 |
Lacaze P et al. J Am Coll Cardiol (2022)
|Ext.		 Reported Trait: Incidence of major adverse cardiovascular events (in placebo arm) — — Hazard ratio (HR, high vs low tertile): 1.7 [1.14, 2.55] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011311 — — 12,815 individuals,
45.1 % Male samples
 Median = 75.1 years European — ASPREE —