PGS Publication: PGP000554

Publication Information (EuropePMC)
Title Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score: Results From the FOURIER Trial.
PubMed ID 31707849(Europe PMC)
doi 10.1161/circulationaha.119.043805
Publication Date Nov. 11, 2019
Journal Circulation
Author(s) Marston NA, Kamanu FK, Nordio F, Gurmu Y, Roselli C, Sever PS, Pedersen TR, Keech AC, Wang H, Lira Pineda A, Giugliano RP, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT.
Released in PGS Catalog: Jan. 11, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004321
(PRS27_CAD)
 PGP000554 |
Marston NA et al. Circulation (2019)
 Coronary heart disease coronary artery disease 27
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004321/ScoringFiles/PGS004321.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020426 PGS004321
(PRS27_CAD)
 PSS011357|
European Ancestry|
14,298 individuals
 PGP000554 |
Marston NA et al. Circulation (2019)
 Reported Trait: Major vascular events (placebo arm) HR: 1.1 [1.03, 1.18] — — — —
PPM020427 PGS004321
(PRS27_CAD)
 PSS011357|
European Ancestry|
14,298 individuals
 PGP000554 |
Marston NA et al. Circulation (2019)
 Reported Trait: Major coronary events (placebo arm) HR: 1.17 [1.08, 1.26] — — — —
PPM020428 PGS004321
(PRS27_CAD)
 PSS011357|
European Ancestry|
14,298 individuals
 PGP000554 |
Marston NA et al. Circulation (2019)
 Reported Trait: Major vascular events (evolocumab vs placebo) — — p-value (pvalue, evolocumab and high PRS vs. placebo and low PRS): 0.07 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011357 — — 14,298 individuals — European — FOURIER —