PGS Publication: PGP000565

Publication Information (EuropePMC)
Title Polygenic risk scores are associated with atrial electrophysiologic substrate abnormalities and outcomes after atrial fibrillation catheter ablation.
PubMed ID 36804918(Europe PMC)
doi 10.1016/j.hrthm.2023.02.011
Publication Date Feb. 16, 2023
Journal Heart Rhythm
Author(s) Al-Kaisey A, Wong GR, Young P, Chieng D, Hawson J, Anderson R, Sugumar H, Nalliah C, Prabhu M, Johnson R, Soka M, Tarr I, Bakshi A, Yu C, Lacaze P, Giannoulatou E, McLellan A, Lee G, Kistler PM, Fatkin D, Kalman JM.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000016
(GPS_AF)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Atrial fibrillation atrial fibrillation 6,730,541
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000016/ScoringFiles/PGS000016.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020706 PGS000016
(GPS_AF)
 PSS011375|
Multi-ancestry (including European)|
95 individuals
 PGP000565 |
Al-Kaisey A et al. Heart Rhythm (2023)
|Ext.		 Reported Trait: Complex signals on electrogram — — beta (PRS above mean vs PRS below mean): 0.24 Age, sex, persistent atrial fibrillation, atrial fibrillation duration —
PPM020704 PGS000016
(GPS_AF)
 PSS011375|
Multi-ancestry (including European)|
95 individuals
 PGP000565 |
Al-Kaisey A et al. Heart Rhythm (2023)
|Ext.		 Reported Trait: Arrhythmia-free survival following catheter ablation — — Hazard ratio (HR, PRS above mean vs PRS below mean): 1.8 [0.9, 3.3] — —
PPM020705 PGS000016
(GPS_AF)
 PSS011375|
Multi-ancestry (including European)|
95 individuals
 PGP000565 |
Al-Kaisey A et al. Heart Rhythm (2023)
|Ext.		 Reported Trait: Left atrial conduction heterogeneity on electrogram — — beta (PRS above mean vs PRS below mean): 0.26 [0.02, 0.55] Age, sex, persistent atrial fibrillation, atrial fibrillation duration —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011375 — — 93 individuals — European Admixed European (n=3) NR —
PSS011375 — — 1 individuals — East Asian — NR —
PSS011375 — — 1 individuals — South Asian Admixed South Asian (n=1) NR —