PGS Publication: PGP000566

Publication Information (EuropePMC)
Title Association of air pollution and genetic risks with incidence of elderly-onset atopic dermatitis: A prospective cohort study.
PubMed ID 36857917(Europe PMC)
doi 10.1016/j.ecoenv.2023.114683
Publication Date Feb. 27, 2023
Journal Ecotoxicol Environ Saf
Author(s) Gu X, Jing D, Xiao Y, Zhou G, Yang S, Liu H, Chen X, Shen M.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004587
(PRS23_AD)
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
 Atopic dermatitis atopic eczema 23
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004587/ScoringFiles/PGS004587.txt.gz

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002755
(Atopic_dermatitis_prscs)
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Atopic dermatitis atopic eczema 1,090,702
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002755/ScoringFiles/PGS002755.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020707 PGS004587
(PRS23_AD)
 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
 Reported Trait: Incident atopic dermatitis — — Hazard ratio (HR, high vs low PRS): 1.153 [1.037, 1.282] sex, age, Townsend index, moderate physical and household income —
PPM020708 PGS004587
(PRS23_AD)
 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
 Reported Trait: Incident atopic dermatitis with air pollution level — — Hazard ratio (HR, high air pollution and high PRS vs low air pollution and low PRS): 1.523 [1.259, 1.84] sex, age, Townsend index, moderate physical and household income —
PPM020709 PGS002755
(Atopic_dermatitis_prscs)
 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
|Ext.		 Reported Trait: Incident atopic dermatitis — — Hazard ratio (HR, high vs low PRS): 1.249 [1.123, 1.391] sex, age, Townsend index, moderate physical and household income —
PPM020710 PGS002755
(Atopic_dermatitis_prscs)
 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
|Ext.		 Reported Trait: Incident atopic dermatitis with air pollution level — — Hazard ratio (HR, high air pollution and high PRS vs low air pollution and low PRS): 1.978 [1.624, 2.411] sex, age, Townsend index, moderate physical and household income —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011376 — Median = 12.0 years 337,910 individuals,
45.6 % Male samples
 Mean = 57.1 years
Sd = 8.0 years		 European — UKB —