PGS Publication: PGP000570

Publication Information (EuropePMC)
Title Genetic susceptibility and lifestyle modify the association of long-term air pollution exposure on major depressive disorder: a prospective study in UK Biobank.
PubMed ID 36810050(Europe PMC)
doi 10.1186/s12916-023-02783-0
Publication Date Feb. 21, 2023
Journal BMC Med
Author(s) Li D, Xie J, Wang L, Sun Y, Hu Y, Tian Y.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004591
(PRS17_MDD)
 PGP000570 |
Li D et al. BMC Med (2023)
 Major depressive disorder major depressive disorder 17
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004591/ScoringFiles/PGS004591.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020721 PGS004591
(PRS17_MDD)
 PSS011382|
Multi-ancestry (including European)|
354,897 individuals
 PGP000570 |
Li D et al. BMC Med (2023)
 Reported Trait: Major depressive disorder with PM2.5 air pollution — — Hazard ratio (HR, PRS in top tertile and high PM2.5 exposure vs PRS in bottom tertile and low PM2.5 exposure): 1.34 [1.23, 1.46] Age, gender, ethnicity, education level, employment status, household income, and Townsend deprivation index —
PPM020720 PGS004591
(PRS17_MDD)
 PSS011382|
Multi-ancestry (including European)|
354,897 individuals
 PGP000570 |
Li D et al. BMC Med (2023)
 Reported Trait: Major depressive disorder — — Hazard ratio (HR, per IQR change in PRS): 1.1 [1.07, 1.12] Age, gender, ethnicity, education level, employment status, household income, Townsend deprivation index, genotyping batch, and first 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011382 — —
[
  • 14,172 cases
  • , 326,236 controls
]
 — European — UKB —
PSS011382 — —
[
  • 165 cases
  • , 4,966 controls
]
 — Asian unspecified — UKB —
PSS011382 — —
[
  • 91 cases
  • , 3,014 controls
]
 — African unspecified — UKB —
PSS011382 — —
[
  • 8 cases
  • , 775 controls
]
 — East Asian
(Chinese)		 — UKB —
PSS011382 — —
[
  • 274 cases
  • , 5,196 controls
]
 — Not reported — UKB —