PGS Publication: PGP000571

Publication Information (EuropePMC)
Title Polygenic risk score as a determinant of risk of keratinocyte cancer in an Australian population-based cohort.
PubMed ID 35881107(Europe PMC)
doi 10.1111/jdv.18466
Publication Date Aug. 4, 2022
Journal J Eur Acad Dermatol Venereol
Author(s) Liyanage UE, Law MH, Antonsson A, Hughes MCB, Gordon S, van der Pols JC, Green AC.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS004592
(PRS_KC)
PGP000571 |
Liyanage UE et al. J Eur Acad Dermatol Venereol (2022)
Keratinocyte cancerkeratinocyte carcinoma78
G
-
E
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004592/ScoringFiles/PGS004592.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM020722PGS004592
(PRS_KC)
PSS011383|
European Ancestry|
998 individuals
PGP000571 |
Liyanage UE et al. J Eur Acad Dermatol Venereol (2022)
Reported Trait: Keratinocyte cancerOR: 1.51 [1.3, 1.76]AUROC: 0.74: 0.231Age, sex, self-reported skin tanning ability, clinical grade of neck elastosis, genotyping batch, fi... rst 2 PCsShow more
PPM020723PGS004592
(PRS_KC)
PSS011383|
European Ancestry|
998 individuals
PGP000571 |
Liyanage UE et al. J Eur Acad Dermatol Venereol (2022)
Reported Trait: Keratinocyte cancerOdds ratio (OR, top PRS quintile vs bottom PRS quintile): 3.45 [2.18, 5.5]Age, sex, self-reported skin tanning ability, clinical grade of neck elastosis, genotyping batch, fi... rst 2 PCsShow more
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011383
[
  • 432 cases
  • , 566 controls
]
,
44.0 % Male samples
EuropeanNSCS
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