Publication Information (EuropePMC) | |
Title | Polygenic risk score as a determinant of risk of keratinocyte cancer in an Australian population-based cohort. |
PubMed ID | 35881107(Europe PMC) |
doi | 10.1111/jdv.18466 |
Publication Date | Aug. 4, 2022 |
Journal | J Eur Acad Dermatol Venereol |
Author(s) | Liyanage UE, Law MH, Antonsson A, Hughes MCB, Gordon S, van der Pols JC, Green AC. |
Polygenic Score ID & Name
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PGS Publication ID (PGP)
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Reported Trait
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Mapped Trait(s) (Ontology)
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Number of Variants
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Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link)
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---|---|---|---|---|---|---|
PGS004592 (PRS_KC) | PGP000571 | Liyanage UE et al. J Eur Acad Dermatol Venereol (2022) | Keratinocyte cancer | keratinocyte carcinoma | 78 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004592/ScoringFiles/PGS004592.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score
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PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM020722 | PGS004592 (PRS_KC) | PSS011383| European Ancestry| 998 individuals | PGP000571 | Liyanage UE et al. J Eur Acad Dermatol Venereol (2022) | Reported Trait: Keratinocyte cancer | OR: 1.51 [1.3, 1.76] | AUROC: 0.74 | R²: 0.231 | Age, sex, self-reported skin tanning ability, clinical grade of neck elastosis, genotyping batch, fi... rst 2 PCsShow more | — |
PPM020723 | PGS004592 (PRS_KC) | PSS011383| European Ancestry| 998 individuals | PGP000571 | Liyanage UE et al. J Eur Acad Dermatol Venereol (2022) | Reported Trait: Keratinocyte cancer | — | — | Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 3.45 [2.18, 5.5] | Age, sex, self-reported skin tanning ability, clinical grade of neck elastosis, genotyping batch, fi... rst 2 PCsShow more | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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PSS011383 | — | — | [ ,
44.0 % Male samples | — | European | — | NSCS | — |