Publication Information (EuropePMC) | |
Title | A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment. |
PubMed ID | 37272255(Europe PMC) |
doi | 10.1002/cac2.12448 |
Publication Date | June 4, 2023 |
Journal | Cancer Commun (Lond) |
Author(s) | Niedermaier T, Alwers E, Chen X, Heisser T, Hoffmeister M, Brenner H. |
Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS002265 (PRS140_CRC) |
PGP000294 | Thomas M et al. Am J Hum Genet (2020) |
Colorectal cancer | colorectal cancer | 140 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002265/ScoringFiles/PGS002265.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM020729 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Colorectal cancer | — | AUROC: 0.615 [0.529, 0.7] | — | — | — |
PPM020730 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Advanced adenoma | — | AUROC: 0.589 [0.562, 0.616] | — | — | — |
PPM020731 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Non-advanced adenoma | — | AUROC: 0.555 [0.534, 0.576] | — | — | — |
PPM020732 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Any advanced neoplasms | — | AUROC: 0.591 [0.564, 0.617] | — | — | — |
PPM020733 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Any advanced neoplasms (50 - 59 years) | — | AUROC: 0.586 [0.544, 0.628] | — | — | — |
PPM020734 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Any advanced neoplasms (60 - 79 years) | — | AUROC: 0.597 [0.563, 0.631] | — | — | — |
PPM020735 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Any advanced neoplasms (men) | — | AUROC: 0.593 [0.558, 0.629] | — | — | — |
PPM020736 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Any advanced neoplasms (women) | — | AUROC: 0.593 [0.553, 0.633] | — | — | — |
PPM020737 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Any advanced neoplasms (family history) | — | AUROC: 0.555 [0.471 - 0.639 | — | — | — |
PPM020738 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Any advanced neoplasms (non family history) | — | AUROC: 0.599 [0.57, 0.627] | — | — | — |
PPM020739 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Any advanced neoplasms (previous colonoscopy) | — | AUROC: 0.607 [0.551, 0.663] | — | — | — |
PPM020740 | PGS002265 (PRS140_CRC) |
PSS011386| Ancestry Not Reported| 3,025 individuals |
PGP000573 | Niedermaier T et al. Cancer Commun (Lond) (2023) |Ext. |
Reported Trait: Any advanced neoplasms (no previous colonoscopy) | — | AUROC: 0.585 [0.555, 0.616] | — | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011386 | — | — | 3,025 individuals | — | Not reported | — | BLITZ | — |