PGS Publication: PGP000575

Publication Information (EuropePMC)
Title Polygenic Risk Score and Statin Relative Risk Reduction for Primary Prevention of Myocardial Infarction in a Real-World Population.
PubMed ID 35862449(Europe PMC)
doi 10.1002/cpt.2715
Publication Date Aug. 24, 2022
Journal Clin Pharmacol Ther
Author(s) Oni-Orisan A, Haldar T, Cayabyab MAS, Ranatunga DK, Hoffmann TJ, Iribarren C, Krauss RM, Risch N.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004595
(PRS_CHD)
 PGP000575 |
Oni-Orisan A et al. Clin Pharmacol Ther (2022)
 Coronary heart disease coronary artery disease 164
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004595/ScoringFiles/PGS004595.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020745 PGS004595
(PRS_CHD)
 PSS011389|
European Ancestry|
21,824 individuals
 PGP000575 |
Oni-Orisan A et al. Clin Pharmacol Ther (2022)
 Reported Trait: Myocardial infarction in non-statin users HR: 1.59 [1.42, 1.78] — — Age, sex, hypertension, diabetes, and cigarette smoking status —
PPM020746 PGS004595
(PRS_CHD)
 PSS011389|
European Ancestry|
21,824 individuals
 PGP000575 |
Oni-Orisan A et al. Clin Pharmacol Ther (2022)
 Reported Trait: Major adverse cardiovascular event in non-statin users HR: 1.35 [1.25, 1.46] — — Age, sex, hypertension, diabetes, and cigarette smoking status —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011389 — Median = 8.2 years 21,824 individuals,
43.4 % Male samples
 Median = 63.1 years European — GERA —