PGS Publication: PGP000587

Publication Information (EuropePMC)
Title Accelerometer-measured intensity-specific physical activity, genetic risk and incident type 2 diabetes: a prospective cohort study.
PubMed ID 37277158(Europe PMC)
doi 10.1136/bjsports-2022-106653
Publication Date June 5, 2023
Journal Br J Sports Med
Author(s) Luo M, Yu C, Del Pozo Cruz B, Chen L, Ding D.
Released in PGS Catalog: Feb. 20, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004602
(PRS424_T2D)
 PGP000580 |
Zhuang P et al. Diabetes Care (2021)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 424
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004602/ScoringFiles/PGS004602.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020779 PGS004602
(PRS424_T2D)
 PSS011407|
Multi-ancestry (including European)|
59,325 individuals
 PGP000587 |
Luo M et al. Br J Sports Med (2023)
|Ext.		 Reported Trait: Incident type 2 diabetes — — Hazard ratio (HR, high vs low PRS tertile): 2.43 [2.04, 2.9] Age as the underlying timescale, gender, genotyping array, the first 10 principal components of ancestry, ethnicity, educational attainment, household income, Townsend deprivation index, employment status, assessment center, moking status, alcohol consumption, healthy diet score, hypertension, dyslipidemia, depression, total wear time, seasonality, and total volume of physical activity —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011407 — Mean = 6.8 years
IQR = [6.3, 7.3] years
[
  • 884 cases
  • , 58,441 controls
]
,
44.0 % Male samples
 Mean = 61.1 years
Sd = 7.8 years		 European, Not reported White European (97.1%) UKB —