| Publication Information (EuropePMC) | |
| Title | Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses. |
| PubMed ID | 38862855(Europe PMC) |
| doi | 10.1038/s41588-024-01782-y |
| Publication Date | June 11, 2024 |
| Journal | Nat Genet |
| Author(s) | Ojima T, Namba S, Suzuki K, Yamamoto K, Sonehara K, Narita A, Tohoku Medical Megabank Project Study Group, Biobank Japan Project, Kamatani Y, Tamiya G, Yamamoto M, Yamauchi T, Kadowaki T, Okada Y. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS004617 (PGS_weights_TMM_LowBMI_of_2groups) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 855,161 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004617/ScoringFiles/PGS004617.txt.gz |
| PGS004620 (PGS_weights_BBJ2nd_LowBMI_of_2groups) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 728,824 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004620/ScoringFiles/PGS004620.txt.gz |
| PGS004618 (PGS_weights_BBJ2nd_All_of_1group) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 728,824 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004618/ScoringFiles/PGS004618.txt.gz |
| PGS004619 (PGS_weights_BBJ2nd_HighBMI_of_2groups) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 728,824 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004619/ScoringFiles/PGS004619.txt.gz |
| PGS004615 (PGS_weights_TMM_All_of_1group) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 855,161 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004615/ScoringFiles/PGS004615.txt.gz |
| PGS004616 (PGS_weights_TMM_HighBMI_of_2groups) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 855,161 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004616/ScoringFiles/PGS004616.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM020793 | PGS004615 (PGS_weights_TMM_All_of_1group) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.639 | liability R2 (nested model): 0.081 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020794 | PGS004615 (PGS_weights_TMM_All_of_1group) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.679 | liability R2 (nested model): 0.114 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020795 | PGS004616 (PGS_weights_TMM_HighBMI_of_2groups) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.617 | liability R2 (nested model): 0.048 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020797 | PGS004617 (PGS_weights_TMM_LowBMI_of_2groups) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.632 | liability R2 (nested model): 0.06 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020798 | PGS004617 (PGS_weights_TMM_LowBMI_of_2groups) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.67 | liability R2 (nested model): 0.09 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020799 | PGS004618 (PGS_weights_BBJ2nd_All_of_1group) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.661 | liability R2 (nested model): 0.125 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020800 | PGS004618 (PGS_weights_BBJ2nd_All_of_1group) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.649 | liability R2 (nested model): 0.093 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020801 | PGS004618 (PGS_weights_BBJ2nd_All_of_1group) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.693 | liability R2 (nested model): 0.154 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020802 | PGS004619 (PGS_weights_BBJ2nd_HighBMI_of_2groups) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.625 | liability R2 (nested model): 0.057 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020803 | PGS004619 (PGS_weights_BBJ2nd_HighBMI_of_2groups) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.659 | liability R2 (nested model): 0.094 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020804 | PGS004620 (PGS_weights_BBJ2nd_LowBMI_of_2groups) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.636 | liability R2 (nested model): 0.081 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020792 | PGS004615 (PGS_weights_TMM_All_of_1group) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.657 | liability R2 (nested model): 0.097 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020796 | PGS004616 (PGS_weights_TMM_HighBMI_of_2groups) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.653 | liability R2 (nested model): 0.065 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020805 | PGS004620 (PGS_weights_BBJ2nd_LowBMI_of_2groups) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.682 | liability R2 (nested model): 0.143 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011416 | — | — | [ ,
65.0 % Male samples |
— | East Asian (Japanese) |
— | BBJ | — |
| PSS011417 | — | — | [ ,
50.0 % Male samples |
— | East Asian (Japanese) |
— | ToMMo | — |