PGS Publication: PGP000609

Publication Information (EuropePMC)
Title Trans-ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study.
PubMed ID 37450379(Europe PMC)
doi 10.1002/alz.13378
Publication Date July 14, 2023
Journal Alzheimers Dement
Author(s) Sleiman PM, Qu HQ, Connolly JJ, Mentch F, Pereira A, Lotufo PA, Tollman S, Choudhury A, Ramsay M, Kato N, Ozaki K, Mitsumori R, Jeon JP, Hong CH, Son SJ, Roh HW, Lee DG, Mukadam N, Foote IF, Marshall CR, Butterworth A, Prins BP, Glessner JT, Hakonarson H, Davos Alzheimer Collaborative and IHCC consortium.
Released in PGS Catalog: April 18, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004863
(PRS74_AD)
 PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
 Alzheimer's disease Alzheimer disease 74
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004863/ScoringFiles/PGS004863.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021094 PGS004863
(PRS74_AD)
 PSS011524|
East Asian Ancestry|
528 individuals
 PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
 Reported Trait: Cortical amyloid positivity OR: 1.186 [0.992, 1.418] AUROC: 0.751 [0.705, 0.796] — APOE haplotype, age, sex, 3 PCs —
PPM021095 PGS004863
(PRS74_AD)
 PSS011525|
East Asian Ancestry|
696 individuals
 PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
 Reported Trait: Clinical Dementia Rating global score ≥ 1 OR: 1.04 [0.871, 1.243] AUROC: 0.637 [0.586, 0.689] — APOE haplotype, age, sex, 3 PCs —
PPM021096 PGS004863
(PRS74_AD)
 PSS011522|
South Asian Ancestry|
718 individuals
 PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
 Reported Trait: All-cause dementia OR: 1.11 [0.94, 1.33] AUROC: 0.69 [0.62, 0.76] — APOE haplotype, age, sex, 3 PCs —
PPM021097 PGS004863
(PRS74_AD)
 PSS011523|
East Asian Ancestry|
2,000 individuals
 PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
 Reported Trait: Alzheimer's disease or mild cognitive impairment OR: 1.12 AUROC: 0.625 [0.601, 0.65] — APOE haplotype, age, sex, 3 PCs —
PPM021098 PGS004863
(PRS74_AD)
 PSS011526|
European Ancestry|
229,265 individuals
 PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
 Reported Trait: Alzheimer's disease or dementia OR: 1.003 [0.99, 1.007] AUROC: 0.746 [0.738, 0.754] — APOE haplotype, age, sex, 3 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011524 — —
[
  • 191 cases
  • , 337 controls
]
 — East Asian
(Korean)		 — BICWALZS —
PSS011525 — —
[
  • 157 cases
  • , 539 controls
]
 — East Asian
(Korean)		 — BICWALZS —
PSS011526 — —
[
  • 2,923 cases
  • , 226,342 controls
]
 — European
(British)		 — UKB —
PSS011522 — —
[
  • 104 cases
  • , 614 controls
]
 — South Asian
(Pakistani, Bangladeshi)		 — G&H —
PSS011523 — —
[
  • 1,000 cases
  • , 1,000 controls
]
 — East Asian
(Japanese)		 — NCGG —