PGS Publication: PGP000614

Publication Information (EuropePMC)
Title Combined application of genetic and polygenic risk scores for type 1 diabetes risk prediction.
PubMed ID 33950547(Europe PMC)
doi 10.1111/dom.14419
Publication Date June 3, 2021
Journal Diabetes Obes Metab
Author(s) Qu HQ, Qu J, Bradfield J, Glessner J, Chang X, March M, Mentch FD, Roizen JD, Connolly JJ, Sleiman P, Hakonarson H.
Released in PGS Catalog: April 18, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000024
(GRS2)
 PGP000014 |
Sharp SA et al. Diabetes Care (2019)
 Type 1 diabetes (T1D) type 1 diabetes mellitus 85
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000024/ScoringFiles/PGS000024.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021124 PGS000024
(GRS2)
 PSS011531|
European Ancestry|
9,465 individuals
 PGP000614 |
Qu HQ et al. Diabetes Obes Metab (2021)
|Ext.		 Reported Trait: Type 1 diabetes β: -0.22 AUROC: 0.87 — — —
PPM021125 PGS000024
(GRS2)
 PSS011532|
European Ancestry|
9,450 individuals
 PGP000614 |
Qu HQ et al. Diabetes Obes Metab (2021)
|Ext.		 Reported Trait: Type 1 diabetes β: -0.234 AUROC: 0.862 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011531 Cases were individuals with T1D —
[
  • 3,299 cases
  • , 6,166 controls
]
,
53.51 % Male samples
 — European — NR —
PSS011532 Cases were individuals with T1D —
[
  • 3,293 cases
  • , 6,157 controls
]
,
53.79 % Male samples
 — European — NR —