PGS Publication: PGP000622

Publication Information (EuropePMC)
Title Combined use of the ELF test and CLivD score improves prediction of liver-related outcomes in the general population.
PubMed ID 37485795(Europe PMC)
doi 10.1111/liv.15681
Publication Date July 23, 2023
Journal Liver Int
Author(s) Åberg F, Saarinen K, Jula A, Lundqvist A, Vihervaara T, Erlund I, Färkkilä M.
Released in PGS Catalog: May 8, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000872
(PRS-5)
 PGP000215 |
Bianco C et al. J Hepatol (2020)
 Non-alcoholic fatty liver disease non-alcoholic fatty liver disease 5
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000872/ScoringFiles/PGS000872.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021276 PGS000872
(PRS-5)
 PSS011674|
European Ancestry|
5,209 individuals
 PGP000622 |
Åberg F et al. Liver Int (2023)
|Ext.		 Reported Trait: Liver-related hospitalization, hepatocellular cancer or liver-related death HR: 5.05 [1.55, 16.5] — — Enhanced liver fibrosis (ELF) test, chronic liver disease (CLivD) score PGS did not increase predictive performance over ELF test + CLivD score

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011674 — —
[
  • 56 cases
  • , 5,153 controls
]
 — European
(Finnish)		 — Health2000 —