PGS Publication: PGP000634

Publication Information (EuropePMC)
Title Associations of Clinical Risk Factors and Novel Biomarkers With Age at Onset of Type 2 Diabetes.
PubMed ID 37453087(Europe PMC)
doi 10.1210/clinem/dgad422
Publication Date Dec. 1, 2023
Journal J Clin Endocrinol Metab
Author(s) Chen JX, Geng T, Zhang YB, Wang Y, Li R, Qiu Z, Wang Y, Yang K, Zhang BF, Ruan HL, Zhou YF, Pan A, Liu G, Liao YF.
Released in PGS Catalog: May 22, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004602
(PRS424_T2D)
 PGP000580 |
Zhuang P et al. Diabetes Care (2021)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 424
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004602/ScoringFiles/PGS004602.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021336 PGS004602
(PRS424_T2D)
 PSS011692|
European Ancestry|
433,150 individuals
 PGP000634 |
Chen JX et al. J Clin Endocrinol Metab (2023)
|Ext.		 Reported Trait: Age at onset of type 2 diabetes ≤ 50 years HR: 1.26 [1.13, 1.41] — — Sex, ethnicity, education, Townsend deprivation index, 4 age groups, follow-up time category, HbA1c, BMI, systolic blood pressure, smoking status, physical activity, diet, use of antihypertensive drugs, use of lipid-lowering drugs, cardiovascular disease, parental history of diabetes —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011692 ICD-10 code, E11 — 433,150 individuals — European
(British)		 — UKB —