PGS Publication: PGP000636

Publication Information (EuropePMC)
Title Association between antibiotic use during early life and early-onset colorectal cancer risk overall and according to polygenic risk and FUT2 genotypes.
PubMed ID 37504220(Europe PMC)
doi 10.1002/ijc.34648
Publication Date July 28, 2023
Journal Int J Cancer
Author(s) Jiang F, Boakye D, Sun J, Wang L, Yu L, Zhou X, Zhao J, Bian Z, Song P, He Y, Zhu Y, Chen J, Yuan S,...  Song M, Larsson SC, Giovannucci EL, Theodoratou E, Ding K, Li X.Show more
Released in PGS Catalog: May 22, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS004904
(PRS127_CRC)
PGP000636 |
Jiang F et al. Int J Cancer (2023)
Colorectal cancercolorectal carcinoma127
G
-
E
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004904/ScoringFiles/PGS004904.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM021341PGS004904
(PRS127_CRC)
PSS011697|
European Ancestry|
113,256 individuals
PGP000636 |
Jiang F et al. Int J Cancer (2023)
Reported Trait: Incident and prevelant early-onset colorectal cancerOR: 2.29 [1.98, 2.64]Age, sex, education, family history, type 1 diabetes, 5 PCs
PPM021342PGS004904
(PRS127_CRC)
PSS011697|
European Ancestry|
113,256 individuals
PGP000636 |
Jiang F et al. Int J Cancer (2023)
Reported Trait: Incident early-onset colorectal cancerOR: 2.51 [1.77, 3.56]Age, sex, education, family history, type 1 diabetes, 5 PCs
PPM021343PGS004904
(PRS127_CRC)
PSS011697|
European Ancestry|
113,256 individuals
PGP000636 |
Jiang F et al. Int J Cancer (2023)
Reported Trait: Incident and prevelant early-onset colorectal adenomaOR: 1.59 [1.48, 1.71]Age, sex, education, family history, type 1 diabetes, 5 PCs
PPM021344PGS004904
(PRS127_CRC)
PSS011697|
European Ancestry|
113,256 individuals
PGP000636 |
Jiang F et al. Int J Cancer (2023)
Reported Trait: Incident early-onset colorectal adenomaOR: 1.57 [1.39, 1.77]Age, sex, education, family history, type 1 diabetes, 5 PCs
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011697113,256 individualsEuropeanUKB
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