PGS Publication: PGP000639

Publication Information (EuropePMC)
Title Genetic determinants of thyroid function in children.
PubMed ID 37530217(Europe PMC)
doi 10.1093/ejendo/lvad086
Publication Date Aug. 1, 2023
Journal Eur J Endocrinol
Author(s) Mulder TA, Campbell PJ, Taylor PN, Peeters RP, Wilson SG, Medici M, Dayan C, Jaddoe VVW, Walsh JP, Martin NG, Tiemeier H, Korevaar TIM.
Released in PGS Catalog: May 22, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
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South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004906
(PRS60_TSH)
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Thyroid stimulating hormone concentration thyroid stimulating hormone measurement 60
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004906/ScoringFiles/PGS004906.txt.gz
PGS004907
(PRS31_FT4)
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Free thyroxine concentration thyroxine measurement 31
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004907/ScoringFiles/PGS004907.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021356 PGS004906
(PRS60_TSH)
 PSS011701|
European Ancestry|
7,231 individuals
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Reported Trait: Thyroid stimulating hormone concentration β: 0.16 (0.01) — — — —
PPM021357 PGS004906
(PRS60_TSH)
 PSS011701|
European Ancestry|
7,231 individuals
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Reported Trait: Free thyroxine (FT4) concentration β: -0.04 (0.01) — — — —
PPM021358 PGS004907
(PRS31_FT4)
 PSS011701|
European Ancestry|
7,231 individuals
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Reported Trait: Free thyroxine (FT4) concentration β: 0.12 (0.01) — — — —
PPM021359 PGS004907
(PRS31_FT4)
 PSS011701|
European Ancestry|
7,231 individuals
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Reported Trait: Thyroid stimulating hormone concentration β: 0.03 (0.01) — — — —
PPM021360 PGS004907
(PRS31_FT4)
 PSS011701|
European Ancestry|
7,231 individuals
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Reported Trait: Free tri-iodothyronine (FT3) concentration β: -0.04 (0.01) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011701 — — 1,680 individuals,
49.3 % Male samples
 Median = 12.1 years
95% Range = [12.0, 12.5] years		 European — BLTS —
PSS011701 — — 2,169 individuals,
50.8 % Male samples
 Median = 6.0 years
95% Range = [5.7, 7.5] years		 European — Generation_R —
PSS011701 — — 3,382 individuals,
52.0 % Male samples
 Median = 7.5 years
95% Range = [7.3, 8.9] years		 European — ALSPAC —