PGS Publication: PGP000641

Publication Information (EuropePMC)
Title Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity.
PubMed ID 30815984(Europe PMC)
doi 10.1111/adb.12741
Publication Date Feb. 27, 2019
Journal Addict Biol
Author(s) El-Boraie A, Taghavi T, Chenoweth MJ, Fukunaga K, Mushiroda T, Kubo M, Lerman C, Nollen NL, Benowitz...  NL, Tyndale RF.Show more
Released in PGS Catalog: May 22, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS004909
(EUR_wGRS7)
PGP000641 |
El-Boraie A et al. Addict Biol (2019)
Nicotine metabolite rationicotine metabolite ratio8
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004909/ScoringFiles/PGS004909.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM021363PGS004909
(EUR_wGRS7)
PSS011703|
European Ancestry|
196 individuals
PGP000641 |
El-Boraie A et al. Addict Biol (2019)
Reported Trait: Nicotine metabolite ratio in treatment-seeking smokers——R²: 0.411Sex, age, body mass index—
PPM021364PGS004909
(EUR_wGRS7)
PSS011703|
European Ancestry|
196 individuals
PGP000641 |
El-Boraie A et al. Addict Biol (2019)
Reported Trait: Nicotine metabolism (slow vs normal) in treatment seeking smokers—AUROC: 0.78 [0.71, 0.85]——Slow metabolisers with a nicotine metabolite ratio (NMR) <0.31 vs normal metabolisers with a NMR ... ≥0.31.Show more
PPM021365PGS004909
(EUR_wGRS7)
PSS011703|
European Ancestry|
196 individuals
PGP000641 |
El-Boraie A et al. Addict Biol (2019)
Reported Trait: Nicotine metabolism (slow vs normal) in treatment seeking smokers—AUROC: 0.78 [0.71, 0.86]——Slow metabolisers with a nicotine metabolite ratio (NMR) <0.26 vs normal metabolisers with a NMR ... ≥0.26.Show more
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011703Participants were treatment seeking smokers. Using a nicotine metabolite ratio (NMR) cut-point of 0.... 31, individuals with slow nicotine metabolism were defined as having a NMR <0.31 whilst individuals with normal rates of nicotine metabolism were defined as having a NMR ≥0.31. Using a nicotine metabolite ratio (NMR) cut-point of 0.26, individuals with slow nicotine metabolism were defined as having a NMR <0.26 whilst individuals with normal rates of nicotine metabolism were defined as having a NMR ≥0.26.Show more—196 individuals—European—Q2L—
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