PGS Publication: PGP000646

Publication Information (EuropePMC)
Title Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations.
PubMed ID 37578347(Europe PMC)
doi 10.1158/1055-9965.epi-23-0174
Publication Date Nov. 1, 2023
Journal Cancer Epidemiol Biomarkers Prev
Author(s) Trendowski MR, Lusk CM, Wenzlaff AS, Neslund-Dudas C, Gadgeel SM, Soubani AO, Schwartz AG.
Released in PGS Catalog: June 12, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000740
(PRS128_LC)
 PGP000148 |
Hung RJ et al. Cancer Res (2021)
 Lung cancer lung carcinoma 128
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000740/ScoringFiles/PGS000740.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021377 PGS000740
(PRS128_LC)
 PSS011713|
European Ancestry|
1,915 individuals
 PGP000646 |
Trendowski MR et al. Cancer Epidemiol Biomarkers Prev (2023)
|Ext.		 Reported Trait: Lung cancer OR: 1.16 [1.04, 1.29] — — Age, sex, pack-years, history of COPD, family history of lung cancer, 5 PCs Only 80 of 128 SNPs were available for analysis
PPM021378 PGS000740
(PRS128_LC)
 PSS011712|
African Ancestry|
1,123 individuals
 PGP000646 |
Trendowski MR et al. Cancer Epidemiol Biomarkers Prev (2023)
|Ext.		 Reported Trait: Lung cancer OR: 0.99 [0.85, 1.15] — — Age, sex, pack-years, history of COPD, family history of lung cancer, 5 PCs Only 80 of 128 SNPs were available for analysis

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011713 — —
[
  • 1,103 cases
  • , 812 controls
]
,
47.2 % Male samples
 — European — INHALE —
PSS011712 — —
[
  • 558 cases
  • , 565 controls
]
,
43.5 % Male samples
 — African unspecified — INHALE —