PGS Publication: PGP000649

Publication Information (EuropePMC)
Title Genetic variants in glutamate-, Aβ-, and tau-related pathways determine polygenic risk for Alzheimer's disease.
PubMed ID 33303219(Europe PMC)
doi 10.1016/j.neurobiolaging.2020.11.009
Publication Date Nov. 12, 2020
Journal Neurobiol Aging
Author(s) Lawingco T, Chaudhury S, Brookes KJ, Guetta-Baranes T, Guerreiro R, Bras J, Hardy J, Francis P, Thom... as A, Belbin O, Morgan K.Show more
Released in PGS Catalog: June 12, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS004918
(PRS8_Synapse)
PGP000649 |
Lawingco T et al. Neurobiol Aging (2020)
Late-onset Alzheimers disease (based on SNPs in genes involved in synaptic function)late-onset Alzheimer's disease8
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004918/ScoringFiles/PGS004918.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM021384PGS004918
(PRS8_Synapse)
PSS011719|
European Ancestry|
136 individuals
PGP000649 |
Lawingco T et al. Neurobiol Aging (2020)
Reported Trait: Late-onset Alzheimer's disease—AUROC: 0.731———
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011719Samples used in this study were extracted from autopsied brain tissue. Samples were taken from cogni... tively normal individuals witth a dementia rating of 0 (controls) and from late-onset Alzheimer's disease (LOAD) patients who had a clinical diagnosis of dementia due to AD and neuropathological confirmation of AD.Show more—
[
  • 56 cases
  • , 80 controls
]
,
39.0 % Male samples
—European—BfDR—
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