PGS Publication: PGP000659

Publication Information (EuropePMC)
Title Joint associations between established genetic susceptibility loci, pesticide exposures, and risk of prostate cancer.
PubMed ID 37659638(Europe PMC)
doi 10.1016/j.envres.2023.117063
Publication Date Sept. 1, 2023
Journal Environ Res
Author(s) Hurwitz LM, Beane Freeman LE, Andreotti G, Hofmann JN, Parks CG, Sandler DP, Lubin JH, Liu J, Jones K, Berndt SI, Koutros S.
Released in PGS Catalog: July 31, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000662
(GRS.PCa.269)
 PGP000122 |
Conti DV et al. Nat Genet (2021)
 Prostate cancer prostate carcinoma 269
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000662/ScoringFiles/PGS000662.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021705 PGS000662
(GRS.PCa.269)
 PSS011753|
European Ancestry|
3,368 individuals
 PGP000659 |
Hurwitz LM et al. Environ Res (2023)
|Ext.		 Reported Trait: Prostate cancer — — Odds ratio (OR, PGS above median vs PGS below median): 1.17 [1.02, 1.35] Age at enrollment, state of residence —
PPM021706 PGS000662
(GRS.PCa.269)
 PSS011754|
European Ancestry|
2,794 individuals
 PGP000659 |
Hurwitz LM et al. Environ Res (2023)
|Ext.		 Reported Trait: Aggressive prostate cancer — — Odds ratio (OR, PGS above median vs PGS below median): 1.17 [0.97, 1.41] Age at enrollment, state of residence —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011753 — —
[
  • 1,162 cases
  • , 2,206 controls
]
,
100.0 % Male samples
 — European — AHS —
PSS011754 — —
[
  • 588 cases
  • , 2,206 controls
]
,
100.0 % Male samples
 — European — AHS —