PGS Publication: PGP000660

Publication Information (EuropePMC)
Title Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk.
PubMed ID 37614046(Europe PMC)
doi 10.1111/joim.13715
Publication Date Aug. 24, 2023
Journal J Intern Med
Author(s) Kim Y, Jang H, Wang M, Shi Q, Strain T, Sharp SJ, Yeung SLA, Luo S, Griffin S, Wareham NJ, Wijndaele K, Brage S.
Released in PGS Catalog: July 31, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004925
(PRS300_CHD)
 PGP000660 |
Kim Y et al. J Intern Med (2023)
 Coronary heart disease coronary artery disease 300
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004925/ScoringFiles/PGS004925.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021707 PGS004925
(PRS300_CHD)
 PSS011755|
European Ancestry|
77,500 individuals
 PGP000660 |
Kim Y et al. J Intern Med (2023)
 Reported Trait: Incident coronary heart disease HR: 1.63 [1.49, 1.78] — — Sex, genotype array type, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011755 — — 77,500 individuals,
43.2 % Male samples
 Mean = 56.3 years
Sd = 7.7 years		 European
(British)		 — UKB —