PGS Publication: PGP000666

Publication Information (EuropePMC)
Title GWAS and polygenic risk score of severe COVID-19 in Eastern Europe.
PubMed ID 39364016(Europe PMC)
doi 10.3389/fmed.2024.1409714
Publication Date Sept. 19, 2024
Journal Front Med (Lausanne)
Author(s) Kovalenko E, Shaheen L, Vergasova E, Kamelin A, Rubinova V, Kharitonov D, Kim A, Plotnikov N, Elmuratov A, Borovkova N, Storozheva M, Solonin S, Gilyazova I, Mironov P, Khusnutdinova E, Petrikov S, Ilinskaya A, Ilinsky V, Rakitko A.
Released in PGS Catalog: Oct. 8, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004938
(pgs_data_ldpred)
 PGP000666 |
Kovalenko E et al. Front Med (Lausanne) (2024)
 Severe COVID-19 course COVID-19 955,503
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004938/ScoringFiles/PGS004938.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021730 PGS004938
(pgs_data_ldpred)
 PSS011763|
European Ancestry|
7,124 individuals
 PGP000666 |
Kovalenko E et al. Front Med (Lausanne) (2024)
 Reported Trait: Severe COVID-19 course — AUROC: 0.6 Odds ratio (OR, high vs low tertile): 2.25 PC1-20, sex, gender —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011763 Very severe respiratory confirmed covid vs. not severe respiratory confirmed covid —
[
  • 724 cases
  • , 6,400 controls
]
 — European — Genotek —