PGS Publication: PGP000675

Publication Information (EuropePMC)
Title Does genetic risk modify the effect of skin screening on melanoma detection rates?
PubMed ID 37681503(Europe PMC)
doi 10.1093/bjd/ljad333
Publication Date Dec. 1, 2023
Journal Br J Dermatol
Author(s) Pandeya N, Dusingize JC, Olsen CM, MacGregor S, Neale RE, Law MH, Whiteman DC.
Released in PGS Catalog: Sept. 19, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004953
(PRS21_melanoma)
 PGP000675 |
Pandeya N et al. Br J Dermatol (2023)
 Melanoma melanoma 21
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004953/ScoringFiles/PGS004953.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021766 PGS004953
(PRS21_melanoma)
 PSS011790|
European Ancestry|
15,283 individuals
 PGP000675 |
Pandeya N et al. Br J Dermatol (2023)
 Reported Trait: Any melanoma — — Hazard ratio (HR, high vs low PGS tertile): 1.91 [1.6, 2.27] Age, sex —
PPM021767 PGS004953
(PRS21_melanoma)
 PSS011790|
European Ancestry|
15,283 individuals
 PGP000675 |
Pandeya N et al. Br J Dermatol (2023)
 Reported Trait: Invasive melanoma — — Hazard ratio (HR, high vs low PGS tertile): 1.87 [1.4, 2.5] Age, sex —
PPM021768 PGS004953
(PRS21_melanoma)
 PSS011790|
European Ancestry|
15,283 individuals
 PGP000675 |
Pandeya N et al. Br J Dermatol (2023)
 Reported Trait: In situ melanoma — — Hazard ratio (HR, high vs low PGS tertile): 1.91 [1.53, 2.38] Age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011790 — — 15,283 individuals — European — QSKIN —