PGS Publication: PGP000681

Publication Information (EuropePMC)
Title Risk assessment of venous thromboembolism in inflammatory bowel disease by inherited risk in a population-based incident cohort.
PubMed ID 37900992(Europe PMC)
doi 10.3748/wjg.v29.i39.5494
Publication Date Oct. 1, 2023
Journal World J Gastroenterol
Author(s) Rifkin AS, Shi Z, Wei J, Zheng SL, Helfand BT, Cordova JS, Biank VF, Tafur AJ, Khan O, Xu J.
Released in PGS Catalog: Oct. 8, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003332
(PRS_VTE_EUR_GHOUSE)
 PGP000398 |
Ghouse J et al. Nat Genet (2023)
 Venous thromboembolism venous thromboembolism 1,092,045
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003332/ScoringFiles/PGS003332.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022174 PGS003332
(PRS_VTE_EUR_GHOUSE)
 PSS011827|
Multi-ancestry (including European)|
8,210 individuals
 PGP000681 |
Rifkin AS et al. World J Gastroenterol (2023)
|Ext.		 Reported Trait: Incident venous thromboembolism in individuals with inflammatory bowel disease — AUROC: 0.68 [0.65, 0.71] Hazard ratio (HR, PGS in top 10% vs middle 80%): 1.98 [1.52, 2.57] Sex, body mass index, 10 PCs 1,515 SNPs from F2 and F5 genes excluded

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011827 — —
[
  • 366 cases
  • , 7,435 controls
]
 — European — UKB —
PSS011827 — —
[
  • 12 cases
  • , 397 controls
]
 — Not reported — UKB —