PGS Publication: PGP000687

Publication Information (EuropePMC)
Title Using a Polygenic Risk Score to Improve the Risk Prediction of Non-Small Cell Lung Cancer in Taiwan.
PubMed ID 39348659(Europe PMC)
doi 10.1200/po.24.00236
Publication Date Oct. 2, 2024
Journal JCO Precis Oncol
Author(s) Lee PH, Chen IC, Chen YM, Hsiao TH, Tseng JS, Huang YH, Hsu KH, Lin H, Yang TY, Shao YJ.
Released in PGS Catalog: Oct. 29, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000070
(PRS_LC_C)
 PGP000049 |
Dai J et al. Lancet Respir Med (2019)
 Lung cancer lung adenocarcinoma 19
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000070/ScoringFiles/PGS000070.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022188 PGS000070
(PRS_LC_C)
 PSS011836|
East Asian Ancestry|
1,197 individuals
 PGP000687 |
Lee PH et al. JCO Precis Oncol (2024)
|Ext.		 Reported Trait: Incident non-small cell lung cancer — — Hazard ratio (HR, high vs low PGS quartile): 2.33 [0.6, 9.04] Age, smoking, family history of lung cancer —
PPM022189 PGS000070
(PRS_LC_C)
 PSS011835|
East Asian Ancestry|
1,090 individuals
 PGP000687 |
Lee PH et al. JCO Precis Oncol (2024)
|Ext.		 Reported Trait: Incident non-small cell lung cancer — — Hazard ratio (HR, high vs low PGS quartile): 2.97 [1.25, 7.07] Age, smoking, family history of lung cancer —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011835 — Median = 10.7 years
[
  • 48 cases
  • , 1,042 controls
]
,
0.0 % Male samples
 — East Asian
(Chinese)		 — TPMI —
PSS011836 — Median = 10.0 years
[
  • 30 cases
  • , 1,167 controls
]
,
100.0 % Male samples
 — East Asian
(Chinese)		 — TPMI —