PGS Publication: PGP000687

Publication Information (EuropePMC)
Title Using a Polygenic Risk Score to Improve the Risk Prediction of Non-Small Cell Lung Cancer in Taiwan.
PubMed ID 39348659(Europe PMC)
doi 10.1200/po.24.00236
Publication Date Oct. 2, 2024
Journal JCO Precis Oncol
Author(s) Lee PH, Chen IC, Chen YM, Hsiao TH, Tseng JS, Huang YH, Hsu KH, Lin H, Yang TY, Shao YJ.
Released in PGS Catalog: Oct. 29, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000070
(PRS_LC_C)
PGP000049 |
Dai J et al. Lancet Respir Med (2019)
Lung cancerlung adenocarcinoma19
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000070/ScoringFiles/PGS000070.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM022188PGS000070
(PRS_LC_C)
PSS011836|
East Asian Ancestry|
1,197 individuals
PGP000687 |
Lee PH et al. JCO Precis Oncol (2024)
|Ext.		Reported Trait: Incident non-small cell lung cancer——Hazard ratio (HR, high vs low PGS quartile): 2.33 [0.6, 9.04]Age, smoking, family history of lung cancer—
PPM022189PGS000070
(PRS_LC_C)
PSS011835|
East Asian Ancestry|
1,090 individuals
PGP000687 |
Lee PH et al. JCO Precis Oncol (2024)
|Ext.		Reported Trait: Incident non-small cell lung cancer——Hazard ratio (HR, high vs low PGS quartile): 2.97 [1.25, 7.07]Age, smoking, family history of lung cancer—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011835—Median = 10.7 years
[
  • 48 cases
  • , 1,042 controls
]
,
0.0 % Male samples
—East Asian
(Chinese)		—TPMI—
PSS011836—Median = 10.0 years
[
  • 30 cases
  • , 1,167 controls
]
,
100.0 % Male samples
—East Asian
(Chinese)		—TPMI—
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