PGS Publication: PGP000697

Publication Information (EuropePMC)
Title Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study.
PubMed ID 37813642(Europe PMC)
doi 10.5551/jat.64425
Publication Date Oct. 6, 2023
Journal J Atheroscler Thromb
Author(s) Takase M, Nakaya N, Nakamura T, Kogure M, Hatanaka R, Nakaya K, Chiba I, Kanno I, Nochioka K, Tsuchiya N, Hirata T, Narita A, Obara T, Ishikuro M, Uruno A, Kobayashi T, N Kodama E, Hamanaka Y, Orui M, Ogishima S, Nagaie S, Fuse N, Sugawara J, Kuriyama S, Tsuji I, Tamiya G, Hozawa A, Yamamoto M.
Released in PGS Catalog: Dec. 16, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005108
(PRSdiabetes)
 PGP000697 |
Takase M et al. J Atheroscler Thromb (2023)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 42,845
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005108/ScoringFiles/PGS005108.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022294 PGS005108
(PRSdiabetes)
 PSS011905|
East Asian Ancestry|
7,745 individuals
 PGP000697 |
Takase M et al. J Atheroscler Thromb (2023)
 Reported Trait: Prevalent diabetes — — Odds ratio (OR, high vs low PGS tertile): 3.16 [2.45, 4.12] Age, sex, 6 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011905 Diabetes was defined as non-fasting glucose ≥ 200 mg/dL, HbA1c ≥ 6.5% (48 mmol/mol), and/or self-reported treatment for diabetes — 7,745 individuals,
23.7 % Male samples
 Mean = 57.3 years
Sd = 13.4 years		 East Asian — TMM —