PGS Publication: PGS000080

Publication Information (EuropePMC)
Title Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.
PubMed ID 31969693(Europe PMC)
doi 10.1038/s41380-019-0546-6
Publication Date Jan. 23, 2020
Journal Mol Psychiatry
Author(s) Coleman JRI, Peyrot WJ, Purves KL, Davis KAS, Rayner C, Choi SW, Hübel C, Gaspar HA, Kan C, Van der Auwera S, Adams MJ, Lyall DM, Choi KW, on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dunn EC, Vassos E, Danese A, Maughan B, Grabe HJ, Lewis CM, O'Reilly PF, McIntosh AM, Smith DJ, Wray NR, Hotopf M, Eley TC, Breen G.
Released in PGS Catalog: June 3, 2020

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
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E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000193
(MDD_0.001_Coleman_2020)
 PGS000080 |
Coleman JRI et al. Mol Psychiatry (2020)
 Major depression major depressive disorder 1,138
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000193/ScoringFiles/PGS000193.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000564 PGS000193
(MDD_0.001_Coleman_2020)
 PSS000294|
European Ancestry|
92,957 individuals
 PGS000080 |
Coleman JRI et al. Mol Psychiatry (2020)
 Reported Trait: Major depressive disorder OR: 1.179 — R²: 0.01485
Nagelkerke pseudo-R2 (increase when adding PRS to null model of covariates): 0.00785		 batch, centre, genomic prinicipal components (x6) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000294 Participants completed an online follow-up questionnaire assessing common mental health disorders, including MDD symptoms. Phenotypes were derived from this questionnaire. Individuals with probable MDD met lifetime criteria based on their responses to questions derived from the Composite International Diagnostic Interview. We excluded cases if they self-reported diagnoses of schizophrenia, other psychoses, or bipolar disorder. Controls were excluded if they self-reported any mental illness, taking any drug with an antidepressant indication, or had been hospitalised with a mood disorder or met previously-defined criteria for a mood disorder. —
[
  • 29,475 cases
  • , 63,482 controls
]
,
45.0 % Male samples
 Range = [46.0, 80.0] years European — UKB —