| Predicted Trait | |
| Reported Trait | Mean corpuscular hemoglobin |
| Mapped Trait(s) | mean corpuscular hemoglobin (EFO_0004527) |
| Additional Trait Information | MCH |
| Score Construction | |
| PGS Name | mch |
| Development Method | |
| Name | Regularized Regression (Elastic Net) |
| Parameters | Bi-allelic variants (MAF > 0.01, INFO > 0.4, missingness rate < 0.1) with LD thinning (r2 t... hreshold = 0.5)Show more |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 27,081 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000051 |
| Citation (link to publication) | Xu Y et al. Cell Genom (2022) |
Study Identifiers
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Sample Numbers
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Sample Ancestry
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Cohort(s)
|
|---|---|---|---|
| — | 406,517 individuals, 46.0 % Male samples | European | UKB |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
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Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| — | 325,214 individuals, 46.0 % Male samples | European | UKB | — | Mean = 57.24 years Range = [38.87, 72.91] years | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000230 | PSS000164| European Ancestry| 81,303 individuals | PGP000051 | Xu Y et al. Cell Genom (2022) | Reported Trait: Mean corpuscular hemoglobin | — | — | Pearson correlation coefficent (r): 0.54504 | age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical cova... riates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)Show more | UKB Testing Set - these samples were held out from Score Development (regression training) but overl... ap with the samples used for variant selection (GWAS)Show more |
| PPM000231 | PSS000138| European Ancestry| 40,108 individuals | PGP000051 | Xu Y et al. Cell Genom (2022) | Reported Trait: Mean corpuscular hemoglobin | — | — | Pearson correlation coefficent (r): 0.49689 | age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical cova... riates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)Show more | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS000138 | — | — | 40,108 individuals, 50.0 % Male samples | Mean = 43.85 years Range = [18.0, 76.4] years | European | — | INTERVAL | — |
| PSS000164 | — | — | 81,303 individuals, 46.0 % Male samples | Mean = 57.27 years Range = [39.99, 70.44] years | European | — | UKB | — |