Trait: mean corpuscular hemoglobin

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004527
Description The MCH is the average mass of hemoglobin per red blood cell in a sample of blood and is calculated by dividing the total mass of hemoglobin by the RBC count
Trait category
Hematological measurement
Synonyms 2 synonyms
  • MCH
  • mean corpuscular haemoglobin
Mapped term MedDRA:10055624

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000099
(mch)
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 27,081
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000099/ScoringFiles/PGS000099.txt.gz
PGS000174
(mch)
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 628
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000174/ScoringFiles/PGS000174.txt.gz
PGS001219
(GBE_INI30050)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 13,003
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001219/ScoringFiles/PGS001219.txt.gz
PGS001989
(portability-PLR_MCH)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 44,174
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001989/ScoringFiles/PGS001989.txt.gz
PGS002206
(portability-ldpred2_MCH)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 504,929
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002206/ScoringFiles/PGS002206.txt.gz
PGS002339
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 1,109,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002339/ScoringFiles/PGS002339.txt.gz
PGS002371
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM-BBJ)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 920,923
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002371/ScoringFiles/PGS002371.txt.gz
PGS002411
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.0001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 22,349
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002411/ScoringFiles/PGS002411.txt.gz
PGS002460
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 44,827
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002460/ScoringFiles/PGS002460.txt.gz
PGS002509
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 151,362
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002509/ScoringFiles/PGS002509.txt.gz
PGS002558
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 10,888
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002558/ScoringFiles/PGS002558.txt.gz
PGS002607
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.5e-08)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 8,017
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002607/ScoringFiles/PGS002607.txt.gz
PGS002656
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 351,633
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002656/ScoringFiles/PGS002656.txt.gz
PGS002705
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.SBayesR)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 979,778
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002705/ScoringFiles/PGS002705.txt.gz
PGS003560
(cont-decay-MCH)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Mean corpuscular hemoglobin mean corpuscular hemoglobin 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003560/ScoringFiles/PGS003560.txt.gz
PGS003929
(INI30050)
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Mean corpuscular hemoglobin mean corpuscular hemoglobin 17,127
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003929/ScoringFiles/PGS003929.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000230 PGS000099
(mch)
 PSS000164|
European Ancestry|
81,303 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Mean corpuscular hemoglobin — — Pearson correlation coefficent (r): 0.54504 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000231 PGS000099
(mch)
 PSS000138|
European Ancestry|
40,108 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Mean corpuscular hemoglobin — — Pearson correlation coefficent (r): 0.49689 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) —
PPM000552 PGS000174
(mch)
 PSS000290|
European Ancestry|
2,314 individuals
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Reported Trait: Mean corpuscular hemoglobin — — R²: 0.17483 sex, age, 10 genetic PCs —
PPM000530 PGS000174
(mch)
 PSS000291|
European Ancestry|
39,260 individuals
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Reported Trait: Mean corpuscular hemoglobin — — R²: 0.18282 sex, age, 10 genetic PCs —
PPM001773 PGS000174
(mch)
 PSS000911|
Greater Middle Eastern Ancestry|
13,989 individuals
 PGP000147 |
Thareja G et al. Nat Commun (2021)
|Ext.		 Reported Trait: Mean corpuscular hemoglobin — — Pearson correlation coefficent (r): 0.22 — —
PPM008629 PGS001219
(GBE_INI30050)
 PSS006931|
African Ancestry|
6,139 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — R²: 0.03354 [0.02494, 0.04215]
Incremental R2 (full-covars): 0.00833
PGS R2 (no covariates): 0.01254 [0.00717, 0.01792]		 age, sex, UKB array type, Genotype PCs —
PPM008630 PGS001219
(GBE_INI30050)
 PSS006932|
East Asian Ancestry|
1,655 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — R²: 0.0892 [0.06342, 0.11498]
Incremental R2 (full-covars): 0.03143
PGS R2 (no covariates): 0.0524 [0.03184, 0.07296]		 age, sex, UKB array type, Genotype PCs —
PPM008631 PGS001219
(GBE_INI30050)
 PSS006933|
European Ancestry|
24,175 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — R²: 0.16096 [0.1526, 0.16932]
Incremental R2 (full-covars): 0.12049
PGS R2 (no covariates): 0.13012 [0.12233, 0.13791]		 age, sex, UKB array type, Genotype PCs —
PPM008632 PGS001219
(GBE_INI30050)
 PSS006934|
South Asian Ancestry|
7,520 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — R²: 0.11958 [0.1061, 0.13306]
Incremental R2 (full-covars): 0.06684
PGS R2 (no covariates): 0.07101 [0.06005, 0.08197]		 age, sex, UKB array type, Genotype PCs —
PPM008633 PGS001219
(GBE_INI30050)
 PSS006935|
European Ancestry|
65,638 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — R²: 0.18797 [0.18266, 0.19328]
Incremental R2 (full-covars): 0.1678
PGS R2 (no covariates): 0.1703 [0.16513, 0.17547]		 age, sex, UKB array type, Genotype PCs —
PPM010787 PGS001989
(portability-PLR_MCH)
 PSS009377|
European Ancestry|
19,421 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.4309 [0.4194, 0.4423] sex, age, birth date, deprivation index, 16 PCs —
PPM010788 PGS001989
(portability-PLR_MCH)
 PSS009151|
European Ancestry|
4,000 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.384 [0.3572, 0.4102] sex, age, birth date, deprivation index, 16 PCs —
PPM010789 PGS001989
(portability-PLR_MCH)
 PSS008705|
European Ancestry|
6,435 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.317 [0.2948, 0.3388] sex, age, birth date, deprivation index, 16 PCs —
PPM010790 PGS001989
(portability-PLR_MCH)
 PSS008479|
Greater Middle Eastern Ancestry|
1,153 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.2578 [0.2026, 0.3114] sex, age, birth date, deprivation index, 16 PCs —
PPM010791 PGS001989
(portability-PLR_MCH)
 PSS008257|
South Asian Ancestry|
6,078 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.2698 [0.2462, 0.2929] sex, age, birth date, deprivation index, 16 PCs —
PPM010792 PGS001989
(portability-PLR_MCH)
 PSS008035|
East Asian Ancestry|
1,762 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.2299 [0.1849, 0.2739] sex, age, birth date, deprivation index, 16 PCs —
PPM010793 PGS001989
(portability-PLR_MCH)
 PSS007821|
African Ancestry|
2,343 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.1586 [0.1187, 0.198] sex, age, birth date, deprivation index, 16 PCs —
PPM010794 PGS001989
(portability-PLR_MCH)
 PSS008925|
African Ancestry|
3,711 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.1189 [0.087, 0.1506] sex, age, birth date, deprivation index, 16 PCs —
PPM012495 PGS002206
(portability-ldpred2_MCH)
 PSS009377|
European Ancestry|
19,421 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.427 [0.4154, 0.4384] sex, age, birth date, deprivation index, 16 PCs —
PPM012496 PGS002206
(portability-ldpred2_MCH)
 PSS009151|
European Ancestry|
4,000 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.3723 [0.3453, 0.3988] sex, age, birth date, deprivation index, 16 PCs —
PPM012497 PGS002206
(portability-ldpred2_MCH)
 PSS008705|
European Ancestry|
6,435 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.3119 [0.2897, 0.3338] sex, age, birth date, deprivation index, 16 PCs —
PPM012498 PGS002206
(portability-ldpred2_MCH)
 PSS008479|
Greater Middle Eastern Ancestry|
1,153 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.2511 [0.1957, 0.3049] sex, age, birth date, deprivation index, 16 PCs —
PPM012499 PGS002206
(portability-ldpred2_MCH)
 PSS008257|
South Asian Ancestry|
6,078 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.2691 [0.2455, 0.2923] sex, age, birth date, deprivation index, 16 PCs —
PPM012500 PGS002206
(portability-ldpred2_MCH)
 PSS008035|
East Asian Ancestry|
1,762 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.2349 [0.19, 0.2787] sex, age, birth date, deprivation index, 16 PCs —
PPM012501 PGS002206
(portability-ldpred2_MCH)
 PSS007821|
African Ancestry|
2,343 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.1483 [0.1083, 0.1879] sex, age, birth date, deprivation index, 16 PCs —
PPM012502 PGS002206
(portability-ldpred2_MCH)
 PSS008925|
African Ancestry|
3,711 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean corpuscular haemoglobin — — Partial Correlation (partial-r): 0.1335 [0.1017, 0.1651] sex, age, birth date, deprivation index, 16 PCs —
PPM013104 PGS002339
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM)
 PSS009799|
African Ancestry|
5,952 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0196 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013153 PGS002339
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM)
 PSS009800|
East Asian Ancestry|
845 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1122 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013202 PGS002339
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM)
 PSS009801|
European Ancestry|
41,826 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1998 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013251 PGS002339
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM)
 PSS009802|
South Asian Ancestry|
7,485 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1238 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013283 PGS002371
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM-BBJ)
 PSS009799|
African Ancestry|
5,952 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0005 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013306 PGS002371
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM-BBJ)
 PSS009800|
East Asian Ancestry|
845 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1055 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013329 PGS002371
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM-BBJ)
 PSS009801|
European Ancestry|
41,826 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0115 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013352 PGS002371
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.BOLT-LMM-BBJ)
 PSS009802|
South Asian Ancestry|
7,485 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.01 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013392 PGS002411
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.0001)
 PSS009799|
African Ancestry|
5,952 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0029 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013441 PGS002411
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.0001)
 PSS009800|
East Asian Ancestry|
845 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0926 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013490 PGS002411
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.0001)
 PSS009801|
European Ancestry|
41,826 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1367 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013539 PGS002411
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.0001)
 PSS009802|
South Asian Ancestry|
7,485 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0845 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013588 PGS002460
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.001)
 PSS009799|
African Ancestry|
5,952 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013637 PGS002460
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.001)
 PSS009800|
East Asian Ancestry|
845 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0709 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013686 PGS002460
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.001)
 PSS009801|
European Ancestry|
41,826 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1354 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013735 PGS002460
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.001)
 PSS009802|
South Asian Ancestry|
7,485 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0791 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013784 PGS002509
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.01)
 PSS009799|
African Ancestry|
5,952 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013833 PGS002509
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.01)
 PSS009800|
East Asian Ancestry|
845 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0213 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013882 PGS002509
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.01)
 PSS009801|
European Ancestry|
41,826 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0946 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013931 PGS002509
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.0.01)
 PSS009802|
South Asian Ancestry|
7,485 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0334 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013980 PGS002558
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.1e-06)
 PSS009799|
African Ancestry|
5,952 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.013 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014029 PGS002558
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.1e-06)
 PSS009800|
East Asian Ancestry|
845 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0871 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014078 PGS002558
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.1e-06)
 PSS009801|
European Ancestry|
41,826 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1257 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014127 PGS002558
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.1e-06)
 PSS009802|
South Asian Ancestry|
7,485 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0825 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014176 PGS002607
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.5e-08)
 PSS009799|
African Ancestry|
5,952 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0125 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014274 PGS002607
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.5e-08)
 PSS009801|
European Ancestry|
41,826 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.12 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014323 PGS002607
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.5e-08)
 PSS009802|
South Asian Ancestry|
7,485 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0807 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014225 PGS002607
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.P+T.5e-08)
 PSS009800|
East Asian Ancestry|
845 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0847 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014372 PGS002656
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.PolyFun-pred)
 PSS009799|
African Ancestry|
5,952 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0234 age, sex, age*sex, assessment center, genotyping array, 10 PCs See blood_MEAN_CORPUSCULAR_HEMOGLOBIN.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014421 PGS002656
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.PolyFun-pred)
 PSS009800|
East Asian Ancestry|
845 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1192 age, sex, age*sex, assessment center, genotyping array, 10 PCs See blood_MEAN_CORPUSCULAR_HEMOGLOBIN.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014470 PGS002656
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.PolyFun-pred)
 PSS009801|
European Ancestry|
41,826 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.2162 age, sex, age*sex, assessment center, genotyping array, 10 PCs See blood_MEAN_CORPUSCULAR_HEMOGLOBIN.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014519 PGS002656
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.PolyFun-pred)
 PSS009802|
South Asian Ancestry|
7,485 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1375 age, sex, age*sex, assessment center, genotyping array, 10 PCs See blood_MEAN_CORPUSCULAR_HEMOGLOBIN.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014568 PGS002705
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.SBayesR)
 PSS009799|
African Ancestry|
5,952 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.0316 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014617 PGS002705
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.SBayesR)
 PSS009800|
East Asian Ancestry|
845 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1188 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014666 PGS002705
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.SBayesR)
 PSS009801|
European Ancestry|
41,826 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1825 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014715 PGS002705
(blood_MEAN_CORPUSCULAR_HEMOGLOBIN.SBayesR)
 PSS009802|
South Asian Ancestry|
7,485 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Mean Corpuscular Hemoglobin — — Incremental R2 (full model vs. covariates alone): 0.1216 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM017572 PGS003560
(cont-decay-MCH)
 PSS010843|
European Ancestry|
3,989 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean corpuscular haemoglobin — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017656 PGS003560
(cont-decay-MCH)
 PSS010675|
European Ancestry|
6,276 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean corpuscular haemoglobin — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM017740 PGS003560
(cont-decay-MCH)
 PSS010591|
Greater Middle Eastern Ancestry|
1,123 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean corpuscular haemoglobin — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM017908 PGS003560
(cont-decay-MCH)
 PSS010507|
South Asian Ancestry|
6,026 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean corpuscular haemoglobin — — partial-R2: 0.07 sex, age, deprivation index, PC1-16 —
PPM017992 PGS003560
(cont-decay-MCH)
 PSS010423|
East Asian Ancestry|
1,750 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean corpuscular haemoglobin — — partial-R2: 0.07 sex, age, deprivation index, PC1-16 —
PPM018076 PGS003560
(cont-decay-MCH)
 PSS010339|
African Ancestry|
2,330 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean corpuscular haemoglobin — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM018160 PGS003560
(cont-decay-MCH)
 PSS010759|
African Ancestry|
3,682 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean corpuscular haemoglobin — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017488 PGS003560
(cont-decay-MCH)
 PSS010927|
European Ancestry|
19,414 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean corpuscular haemoglobin — — partial-R2: 0.19 sex, age, deprivation index, PC1-16 —
PPM017824 PGS003560
(cont-decay-MCH)
 PSS010255|
European Ancestry|
2,263 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean corpuscular haemoglobin — — partial-R2: 0.14 sex, age, deprivation index, PC1-16 —
PPM018964 PGS003929
(INI30050)
 PSS011136|
European Ancestry|
65,932 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean corpuscular hemoglobin — — R²: 0.1843 [0.17903, 0.18957]
PGS R2 (no covariates): 0.16693 [0.1618, 0.17205]
Incremental R2 (full-covars): 0.16424		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM018965 PGS003929
(INI30050)
 PSS011109|
European Ancestry|
2,813 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean corpuscular hemoglobin — — R²: 0.20494 [0.17875, 0.23114]
PGS R2 (no covariates): 0.18314 [0.1577, 0.20858]
Incremental R2 (full-covars): 0.17698		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM018966 PGS003929
(INI30050)
 PSS011113|
South Asian Ancestry|
1,433 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean corpuscular hemoglobin — — R²: 0.11596 [0.08543, 0.14649]
PGS R2 (no covariates): 0.08633 [0.05911, 0.11356]
Incremental R2 (full-covars): 0.08195		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM018967 PGS003929
(INI30050)
 PSS011155|
African Ancestry|
1,157 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean corpuscular hemoglobin — — R²: 0.07189 [0.04397, 0.09982]
PGS R2 (no covariates): 0.05454 [0.02976, 0.07932]
Incremental R2 (full-covars): 0.05029		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM018968 PGS003929
(INI30050)
 PSS011166|
Multi-ancestry (excluding European)|
7,746 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean corpuscular hemoglobin — — R²: 0.17414 [0.15905, 0.18923]
PGS R2 (no covariates): 0.1276 [0.11395, 0.14124]
Incremental R2 (full-covars): 0.0916		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011155 — — 1,157 individuals — African unspecified — UKB —
PSS010927 — — 19,414 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010675 — — 6,276 individuals,
45.0 % Male samples
 Mean = 54.5 years
Sd = 8.4 years		 European Italian UKB —
PSS008925 — — 3,711 individuals — African unspecified Nigeria (West Africa) UKB —
PSS010423 — — 1,750 individuals,
33.0 % Male samples
 Mean = 52.5 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS011166 — — 7,746 individuals — East Asian, Other admixed ancestry East Asian, Other admixed ancestry UKB —
PSS008035 — — 1,762 individuals — East Asian China (East Asia) UKB —
PSS000290 — — 2,314 individuals — European
(French Canadian)		 — CARTaGENE —
PSS000291 — — 39,260 individuals — European — INTERVAL —
PSS000911 — — 13,989 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —
PSS009799 — — 5,952 individuals — African unspecified — UKB —
PSS009800 — — 845 individuals — East Asian — UKB —
PSS008705 — — 6,435 individuals — European Italy (South Europe) UKB —
PSS009801 — — 41,826 individuals — European Non-British European UKB —
PSS009802 — — 7,485 individuals — South Asian — UKB —
PSS010843 — — 3,989 individuals,
38.0 % Male samples
 Mean = 54.3 years
Sd = 7.5 years		 European Polish UKB —
PSS010591 — — 1,123 individuals,
59.0 % Male samples
 Mean = 52.0 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010339 — — 2,330 individuals,
37.0 % Male samples
 Mean = 52.4 years
Sd = 8.0 years		 African American or Afro-Caribbean Caribbean UKB —
PSS000138 — — 40,108 individuals,
50.0 % Male samples
 Mean = 43.85 years
Range = [18.0, 76.4] years		 European — INTERVAL —
PSS007821 — — 2,343 individuals — African American or Afro-Caribbean Carribean UKB —
PSS006931 — — 6,139 individuals — African unspecified — UKB —
PSS006932 — — 1,655 individuals — East Asian — UKB —
PSS006933 — — 24,175 individuals — European non-white British ancestry UKB —
PSS006934 — — 7,520 individuals — South Asian — UKB —
PSS008479 — — 1,153 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS006935 — — 65,638 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS009377 — — 19,421 individuals — European UK (+ Ireland) UKB —
PSS000164 — — 81,303 individuals,
46.0 % Male samples
 Mean = 57.27 years
Range = [39.99, 70.44] years		 European — UKB —
PSS011109 — — 2,813 individuals — European
(non-white British ancestry)		 — UKB —
PSS011113 — — 1,433 individuals — South Asian — UKB —
PSS010759 — — 3,682 individuals,
47.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010507 — — 6,026 individuals,
55.0 % Male samples
 Mean = 53.3 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010255 — — 2,263 individuals,
45.0 % Male samples
 Mean = 58.0 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS009151 — — 4,000 individuals — European Poland (NE Europe) UKB —
PSS011136 — — 65,932 individuals — European
(white British ancestry)		 — UKB —
PSS008257 — — 6,078 individuals — South Asian India (South Asia) UKB —