Polygenic Score (PGS) ID: PGS000127

Predicted Trait
Reported Trait HbA1c
Mapped Trait(s) HbA1c measurement (EFO_0004541)
Additional Trait Information Score composed of erythrocytic variants associated with HbA1c, used to predict diabetes incidence
Released in PGS Catalog: March 27, 2020
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Score Details

Score Construction
PGS Name GS-E-EUR
Development Method
Name GWAS
Parameters Study-wide multi-ancestry GWAS significant SNPs
Variants
Original Genome Build NCBI36
Number of Variants 21
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000064
Citation (link to publication) Wheeler E et al. PLoS Med (2017)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
88,355 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007954
Europe PMC: 28898252
 88,355 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000407 PSS000236|
European Ancestry|
37,357 individuals
 PGP000064 |
Wheeler E et al. PLoS Med (2017)
 Reported Trait: Incident type 2 diabetes OR: 1.0 [0.99, 1.01] — — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000236 Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes Range = [10.0, 15.0] years
[
  • 13,145 cases
  • , 24,212 controls
]
,
43.47 % Male samples
 Mean = 54.63 years
Sd = 8.27 years		 European — ARIC, FHS, InterAct, MESA Partial overlap with discovery GWAS