Polygenic Score (PGS) ID: PGS000127

Predicted Trait
Reported Trait HbA1c
Mapped Trait(s) HbA1c measurement (EFO_0004541)
Additional Trait Information Score composed of erythrocytic variants associated with HbA1c, used to predict diabetes incidence
Released in PGS Catalog: March 27, 2020
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GS-E-EUR
Development Method
Name GWAS
Parameters Study-wide multi-ancestry GWAS significant SNPs
Variants
Original Genome Build NCBI36
Number of Variants 21
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000064
Citation (link to publication) Wheeler E et al. PLoS Med (2017)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
88,355 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST007954
Europe PMC: 28898252
88,355 individualsEuropeanNR
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM000407PSS000236|
European Ancestry|
37,357 individuals
PGP000064 |
Wheeler E et al. PLoS Med (2017)
Reported Trait: Incident type 2 diabetesOR: 1.0 [0.99, 1.01]——age, sex—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000236Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L,...  antidiabetic medication use, or a physician diagnosis of type 2 diabetesShow moreRange = [10.0, 15.0] years
[
  • 13,145 cases
  • , 24,212 controls
]
,
43.47 % Male samples
Mean = 54.63 years
Sd = 8.27 years		European—ARIC, FHS, InterAct, MESAPartial overlap with discovery GWAS
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