| Publication Information (EuropePMC) | |
| Title | Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. |
| PubMed ID | 28898252(Europe PMC) |
| doi | 10.1371/journal.pmed.1002383 |
| Publication Date | Sept. 12, 2017 |
| Journal | PLoS Med |
| Author(s) | Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, Porneala BC, Sharp SJ, Jia Y, Kabagambe EK, Chang LC, Chen WM, Elks CE, Evans DS, Fan Q, Giulianini F, Go MJ, Hottenga JJ, Hu Y, Jackson AU, Kanoni S, Kim YJ, Kleber ME, Ladenvall C, Lecoeur C, Lim SH, Lu Y, Mahajan A, Marzi C, Nalls MA, Navarro P, Nolte IM, Rose LM, Rybin DV, Sanna S, Shi Y, Stram DO, Takeuchi F, Tan SP, van der Most PJ, Van Vliet-Ostaptchouk JV, Wong A, Yengo L, Zhao W, Goel A, Martinez Larrad MT, Radke D, Salo P, Tanaka T, van Iperen EPA, Abecasis G, Afaq S, Alizadeh BZ, Bertoni AG, Bonnefond A, Böttcher Y, Bottinger EP, Campbell H, Carlson OD, Chen CH, Cho YS, Garvey WT, Gieger C, Goodarzi MO, Grallert H, Hamsten A, Hartman CA, Herder C, Hsiung CA, Huang J, Igase M, Isono M, Katsuya T, Khor CC, Kiess W, Kohara K, Kovacs P, Lee J, Lee WJ, Lehne B, Li H, Liu J, Lobbens S, Luan J, Lyssenko V, Meitinger T, Miki T, Miljkovic I, Moon S, Mulas A, Müller G, Müller-Nurasyid M, Nagaraja R, Nauck M, Pankow JS, Polasek O, Prokopenko I, Ramos PS, Rasmussen-Torvik L, Rathmann W, Rich SS, Robertson NR, Roden M, Roussel R, Rudan I, Scott RA, Scott WR, Sennblad B, Siscovick DS, Strauch K, Sun L, Swertz M, Tajuddin SM, Taylor KD, Teo YY, Tham YC, Tönjes A, Wareham NJ, Willemsen G, Wilsgaard T, Hingorani AD, EPIC-CVD Consortium, EPIC-InterAct Consortium, Lifelines Cohort Study, Egan J, Ferrucci L, Hovingh GK, Jula A, Kivimaki M, Kumari M, Njølstad I, Palmer CNA, Serrano Ríos M, Stumvoll M, Watkins H, Aung T, Blüher M, Boehnke M, Boomsma DI, Bornstein SR, Chambers JC, Chasman DI, Chen YI, Chen YT, Cheng CY, Cucca F, de Geus EJC, Deloukas P, Evans MK, Fornage M, Friedlander Y, Froguel P, Groop L, Gross MD, Harris TB, Hayward C, Heng CK, Ingelsson E, Kato N, Kim BJ, Koh WP, Kooner JS, Körner A, Kuh D, Kuusisto J, Laakso M, Lin X, Liu Y, Loos RJF, Magnusson PKE, März W, McCarthy MI, Oldehinkel AJ, Ong KK, Pedersen NL, Pereira MA, Peters A, Ridker PM, Sabanayagam C, Sale M, Saleheen D, Saltevo J, Schwarz PE, Sheu WHH, Snieder H, Spector TD, Tabara Y, Tuomilehto J, van Dam RM, Wilson JG, Wilson JF, Wolffenbuttel BHR, Wong TY, Wu JY, Yuan JM, Zonderman AB, Soranzo N, Guo X, Roberts DJ, Florez JC, Sladek R, Dupuis J, Morris AP, Tai ES, Selvin E, Rotter JI, Langenberg C, Barroso I, Meigs JB. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000131 (GS-G-AFR) |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
HbA1c | HbA1c measurement | 19 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000131/ScoringFiles/PGS000131.txt.gz |
| PGS000128 (GS-E-AFR) |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
HbA1c | HbA1c measurement | 22 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000128/ScoringFiles/PGS000128.txt.gz |
| PGS000129 (GS-E-EAS) |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
HbA1c | HbA1c measurement | 17 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000129/ScoringFiles/PGS000129.txt.gz |
| PGS000127 (GS-E-EUR) |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
HbA1c | HbA1c measurement | 21 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000127/ScoringFiles/PGS000127.txt.gz |
| PGS000130 (GS-G-EUR) |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
HbA1c | HbA1c measurement | 19 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000130/ScoringFiles/PGS000130.txt.gz |
| PGS000132 (GS-G-EAS) |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
HbA1c | HbA1c measurement | 19 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000132/ScoringFiles/PGS000132.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000412 | PGS000132 (GS-G-EAS) |
PSS000235| East Asian Ancestry| 5,073 individuals |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
Reported Trait: Incident type 2 diabetes | OR: 1.05 [1.02, 1.07] | — | — | age, sex | — |
| PPM000411 | PGS000131 (GS-G-AFR) |
PSS000234| African Ancestry| 1,906 individuals |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
Reported Trait: Incident type 2 diabetes | OR: 1.0 [0.95, 1.05] | — | — | age, sex | — |
| PPM000410 | PGS000130 (GS-G-EUR) |
PSS000236| European Ancestry| 37,357 individuals |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
Reported Trait: Incident type 2 diabetes | OR: 1.05 [1.04, 1.06] | — | — | age, sex | — |
| PPM000409 | PGS000129 (GS-E-EAS) |
PSS000235| East Asian Ancestry| 5,073 individuals |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
Reported Trait: Incident type 2 diabetes | OR: 1.02 [0.99, 1.05] | — | — | age, sex | — |
| PPM000408 | PGS000128 (GS-E-AFR) |
PSS000234| African Ancestry| 1,906 individuals |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
Reported Trait: Incident type 2 diabetes | OR: 0.98 [0.96, 1.0] | — | — | age, sex | — |
| PPM000407 | PGS000127 (GS-E-EUR) |
PSS000236| European Ancestry| 37,357 individuals |
PGP000064 | Wheeler E et al. PLoS Med (2017) |
Reported Trait: Incident type 2 diabetes | OR: 1.0 [0.99, 1.01] | — | — | age, sex | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000234 | Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes | Range = [10.0, 15.0] years | [ ,
37.93 % Male samples |
Mean = 57.4 years Sd = 7.43 years |
African unspecified | — | ARIC, MESA | Partial overlap with discovery GWAS |
| PSS000235 | Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes | Range = [10.0, 15.0] years | [ ,
47.45 % Male samples |
Mean = 55.6 years Sd = 7.37 years |
East Asian | — | MESA, SCHS | Partial overlap with discovery GWAS |
| PSS000236 | Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes | Range = [10.0, 15.0] years | [ ,
43.47 % Male samples |
Mean = 54.63 years Sd = 8.27 years |
European | — | ARIC, FHS, InterAct, MESA | Partial overlap with discovery GWAS |