Predicted Trait | |
Reported Trait | HbA1c |
Mapped Trait(s) | HbA1c measurement (EFO_0004541) |
Additional Trait Information | Score composed of glycemic variants associated with HbA1c, used to predict diabetes incidence |
Score Construction | |
PGS Name | GS-G-EAS |
Development Method | |
Name | GWAS |
Parameters | Study-wide multi-ancestry GWAS significant SNPs |
Variants | |
Original Genome Build | NCBI36 |
Number of Variants | 19 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000064 |
Citation (link to publication) | Wheeler E et al. PLoS Med (2017) |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | East Asian: 100% 18,472 individuals (100%) |
PGS Evaluation | East Asian: 100% 1 Sample Sets |
Study Identifiers
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Sample Numbers
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Sample Ancestry
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Cohort(s)
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---|---|---|---|
GWAS Catalog: GCST007953 Europe PMC: 28898252 | 18,472 individuals | East Asian | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM000412 | PSS000235| East Asian Ancestry| 5,073 individuals | PGP000064 | Wheeler E et al. PLoS Med (2017) | Reported Trait: Incident type 2 diabetes | OR: 1.05 [1.02, 1.07] | — | — | age, sex | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
|
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PSS000235 | Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L,... antidiabetic medication use, or a physician diagnosis of type 2 diabetesShow more | Range = [10.0, 15.0] years | [ ,
47.45 % Male samples | Mean = 55.6 years Sd = 7.37 years | East Asian | — | MESA, SCHS | Partial overlap with discovery GWAS |