Polygenic Score (PGS) ID: PGS000714

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: Feb. 3, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS55_PC
Development Method
Name Genome-wide significant variants
Parameters p<5e-8, ORs <1.1 or >0.9
Variants
Original Genome Build NR
Number of Variants 55
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000130
Citation (link to publication) Sipeky C et al. Sci Rep (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
22,548 individuals (100%)
PGS Evaluation
European: 100%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST001942
Europe PMC: 23535732
22,548 individualsEuropeanNR
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM001624PSS000840|
European Ancestry|
5,138 individuals
PGP000130 |
Sipeky C et al. Sci Rep (2020)
Reported Trait: Prostate cancerOR: 2.13 [1.9, 2.39]AUROC: 0.618 [0.6, 0.63]———
PPM001625PSS000841|
European Ancestry|
4,683 individuals
PGP000130 |
Sipeky C et al. Sci Rep (2020)
Reported Trait: Prostate cancer (clinical cases)OR: 2.18 [1.93, 2.45]AUROC: 0.622 [0.61, 0.64]———
PPM001626PSS000843|
European Ancestry|
2,855 individuals
PGP000130 |
Sipeky C et al. Sci Rep (2020)
Reported Trait: Prostate cancer (screening trial detected)OR: 1.92 [1.56, 2.37]AUROC: 0.597 [0.57, 0.63]———
PPM001627PSS000842|
European Ancestry|
2,591 individuals
PGP000130 |
Sipeky C et al. Sci Rep (2020)
Reported Trait: Metastatic prostate cancerOR: 1.47AUROC: 0.549———
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000840Cases: clinically diagnosed or screen-detected prostate cancer. Controls: free of cancer—
[
  • 2,738 cases
  • , 2,400 controls
]
,
100.0 % Male samples
—European
(Finnish)		—FinRSPC, PHD—
PSS000841Cases: clinically diagnosed with prostate cancer. Controls: free of cancer.—
[
  • 2,283 cases
  • , 2,400 controls
]
,
100.0 % Male samples
—European
(Finnish)		—FinRSPC, PHD—
PSS000842——
[
  • 191 cases
  • , 2,400 controls
]
,
100.0 % Male samples
—European
(Finnish)		—FinRSPC, PHD—
PSS000843Cases: screen-detected prostate cancer. Controls: free of cancer.—
[
  • 455 cases
  • , 2,400 controls
]
,
100.0 % Male samples
—European
(Finnish)		—FinRSPC—
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