PGS Publication: PGP000130

Publication Information (EuropePMC)
Title Prostate cancer risk prediction using a polygenic risk score.
PubMed ID 33051487(Europe PMC)
doi 10.1038/s41598-020-74172-z
Publication Date Oct. 13, 2020
Journal Sci Rep
Author(s) Sipeky C, Talala KM, Tammela TLJ, Taari K, Auvinen A, Schleutker J.
Released in PGS Catalog: Feb. 3, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000714
(PRS55_PC)
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Prostate cancer prostate carcinoma 55
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000714/ScoringFiles/PGS000714.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001624 PGS000714
(PRS55_PC)
 PSS000840|
European Ancestry|
5,138 individuals
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Reported Trait: Prostate cancer OR: 2.13 [1.9, 2.39] AUROC: 0.618 [0.6, 0.63] — — —
PPM001625 PGS000714
(PRS55_PC)
 PSS000841|
European Ancestry|
4,683 individuals
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Reported Trait: Prostate cancer (clinical cases) OR: 2.18 [1.93, 2.45] AUROC: 0.622 [0.61, 0.64] — — —
PPM001626 PGS000714
(PRS55_PC)
 PSS000843|
European Ancestry|
2,855 individuals
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Reported Trait: Prostate cancer (screening trial detected) OR: 1.92 [1.56, 2.37] AUROC: 0.597 [0.57, 0.63] — — —
PPM001627 PGS000714
(PRS55_PC)
 PSS000842|
European Ancestry|
2,591 individuals
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Reported Trait: Metastatic prostate cancer OR: 1.47 AUROC: 0.549 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000840 Cases: clinically diagnosed or screen-detected prostate cancer. Controls: free of cancer —
[
  • 2,738 cases
  • , 2,400 controls
]
,
100.0 % Male samples
 — European
(Finnish)		 — FinRSPC, PHD —
PSS000841 Cases: clinically diagnosed with prostate cancer. Controls: free of cancer. —
[
  • 2,283 cases
  • , 2,400 controls
]
,
100.0 % Male samples
 — European
(Finnish)		 — FinRSPC, PHD —
PSS000842 — —
[
  • 191 cases
  • , 2,400 controls
]
,
100.0 % Male samples
 — European
(Finnish)		 — FinRSPC, PHD —
PSS000843 Cases: screen-detected prostate cancer. Controls: free of cancer. —
[
  • 455 cases
  • , 2,400 controls
]
,
100.0 % Male samples
 — European
(Finnish)		 — FinRSPC —