Polygenic Score (PGS) ID: PGS000769

Predicted Trait
Reported Trait Response to bronchodilator (albutamol)
Mapped Trait(s) response to bronchodilator (GO_0097366)
Released in PGS Catalog: May 28, 2021
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Score Details

Score Construction
PGS Name PRS16_BDR
Development Method
Name Variants associated with bronchodilator response that have a combined annotation dependent depletion (CADD) score of >10.
Parameters p < 1e-3
Variants
Original Genome Build NR
Number of Variants 16
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000176
Citation (link to publication) Sordillo JE et al. J Pers Med (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,644 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST001597
Europe PMC: 22792082
 1,644 individuals European CAMP, CARE_c, LOCCS, LODO, SHARe

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001986 PSS000990|
Hispanic or Latin American Ancestry|
967 individuals
 PGP000176 |
Sordillo JE et al. J Pers Med (2021)
 Reported Trait: Bronchodilator response ≥ 8% OR: 0.8 [0.69, 0.92] — — Age, body mass index, sex, PCs(1-6), doctor visits for asthma —
PPM001985 PSS000990|
Hispanic or Latin American Ancestry|
967 individuals
 PGP000176 |
Sordillo JE et al. J Pers Med (2021)
 Reported Trait: Bronchodilator response ≥ 12% OR: 0.8 [0.67, 0.95] — — Age, body mass index, sex, PCs(1-6), doctor visits for asthma —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000990 Cases are individuals with asthma and a bronchodilator response of 8% or higher. Asthma was defined as physician-diagnosed asthma and at least two respiratory symptoms or asthma attacks in the previous year. 166 of the 275 cases had a bronchodilator response of 12% or higher. —
[
  • 275 cases
  • , 692 controls
]
,
59.0 % Male samples
 Mean = 9.3 years
Sd = 9.1 years		 Hispanic or Latin American — GACRS —