PGS Publication: PGP000176

Publication Information (EuropePMC)
Title Pharmacogenetic Polygenic Risk Score for Bronchodilator Response in Children and Adolescents with Asthma: Proof-of-Concept.
PubMed ID 33923870(Europe PMC)
doi 10.3390/jpm11040319
Publication Date April 20, 2021
Journal J Pers Med
Author(s) Sordillo JE, Lutz SM, McGeachie MJ, Lasky-Su J, Weiss ST, Celedón JC, Wu AC.
Released in PGS Catalog: May 28, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000769
(PRS16_BDR)
 PGP000176 |
Sordillo JE et al. J Pers Med (2021)
 Response to bronchodilator (albutamol) response to bronchodilator 16
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000769/ScoringFiles/PGS000769.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001986 PGS000769
(PRS16_BDR)
 PSS000990|
Hispanic or Latin American Ancestry|
967 individuals
 PGP000176 |
Sordillo JE et al. J Pers Med (2021)
 Reported Trait: Bronchodilator response ≥ 8% OR: 0.8 [0.69, 0.92] — — Age, body mass index, sex, PCs(1-6), doctor visits for asthma —
PPM001985 PGS000769
(PRS16_BDR)
 PSS000990|
Hispanic or Latin American Ancestry|
967 individuals
 PGP000176 |
Sordillo JE et al. J Pers Med (2021)
 Reported Trait: Bronchodilator response ≥ 12% OR: 0.8 [0.67, 0.95] — — Age, body mass index, sex, PCs(1-6), doctor visits for asthma —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000990 Cases are individuals with asthma and a bronchodilator response of 8% or higher. Asthma was defined as physician-diagnosed asthma and at least two respiratory symptoms or asthma attacks in the previous year. 166 of the 275 cases had a bronchodilator response of 12% or higher. —
[
  • 275 cases
  • , 692 controls
]
,
59.0 % Male samples
 Mean = 9.3 years
Sd = 9.1 years		 Hispanic or Latin American — GACRS —