Polygenic Score (PGS) ID: PGS000822

Predicted Trait
Reported Trait Urinary albumin to creatinine ratio
Mapped Trait(s) urinary albumin to creatinine ratio (EFO_0007778)
Released in PGS Catalog: July 29, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS_UACR
Development Method
Name Genome-wide significant variants
Parameters P < 5e-8
Variants
Original Genome Build GRCh37
Number of Variants 59
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000206
Citation (link to publication) Teumer A et al. Nat Commun (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 97%
African: 1.2%
East Asian: 1.1%
South Asian: 0.4%
Hispanic or Latin American: 0.3%
564,257 individuals (100%)
PGS Evaluation
European: 87.5%
African: 12.5%
8 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST008790
Europe PMC: 31511532
547,361 individualsEuropean38 cohorts
  • AA-DHS
  • ,ADVANCE
  • ,AGES
  • ,AMISH
  • ,ARIC
  • ,BioVU
  • ,CHRIS
  • ,CHS
  • ,DIACORE
  • ,ESTHER
  • ,FHS
  • ,FINCAVAS
  • ,GCKD
  • ,Generation_R
  • ,JHS
  • ,KORA
  • ,LIFE-Adult
  • ,LIFE-Child
  • ,LifeLines
  • ,Living-Biobank
  • ,MESA
  • ,MICROS
  • ,MyCode
  • ,NEO
  • ,PIVUS
  • ,POPGEN
  • ,PREVEND
  • ,RS
  • ,SCES
  • ,SHIP
  • ,SIMES
  • ,SINDI
  • ,SKIPOGH
  • ,SORBS
  • ,SP2
  • ,UKB
  • ,ULSAM
  • ,deCODE
GWAS Catalog: GCST008790
Europe PMC: 31511532
6,795 individualsAfrican American or Afro-Caribbean38 cohorts
  • AA-DHS
  • ,ADVANCE
  • ,AGES
  • ,AMISH
  • ,ARIC
  • ,BioVU
  • ,CHRIS
  • ,CHS
  • ,DIACORE
  • ,ESTHER
  • ,FHS
  • ,FINCAVAS
  • ,GCKD
  • ,Generation_R
  • ,JHS
  • ,KORA
  • ,LIFE-Adult
  • ,LIFE-Child
  • ,LifeLines
  • ,Living-Biobank
  • ,MESA
  • ,MICROS
  • ,MyCode
  • ,NEO
  • ,PIVUS
  • ,POPGEN
  • ,PREVEND
  • ,RS
  • ,SCES
  • ,SHIP
  • ,SIMES
  • ,SINDI
  • ,SKIPOGH
  • ,SORBS
  • ,SP2
  • ,UKB
  • ,ULSAM
  • ,deCODE
GWAS Catalog: GCST008790
Europe PMC: 31511532
6,324 individualsEast Asian38 cohorts
  • AA-DHS
  • ,ADVANCE
  • ,AGES
  • ,AMISH
  • ,ARIC
  • ,BioVU
  • ,CHRIS
  • ,CHS
  • ,DIACORE
  • ,ESTHER
  • ,FHS
  • ,FINCAVAS
  • ,GCKD
  • ,Generation_R
  • ,JHS
  • ,KORA
  • ,LIFE-Adult
  • ,LIFE-Child
  • ,LifeLines
  • ,Living-Biobank
  • ,MESA
  • ,MICROS
  • ,MyCode
  • ,NEO
  • ,PIVUS
  • ,POPGEN
  • ,PREVEND
  • ,RS
  • ,SCES
  • ,SHIP
  • ,SIMES
  • ,SINDI
  • ,SKIPOGH
  • ,SORBS
  • ,SP2
  • ,UKB
  • ,ULSAM
  • ,deCODE
GWAS Catalog: GCST008790
Europe PMC: 31511532
2,335 individualsSouth Asian38 cohorts
  • AA-DHS
  • ,ADVANCE
  • ,AGES
  • ,AMISH
  • ,ARIC
  • ,BioVU
  • ,CHRIS
  • ,CHS
  • ,DIACORE
  • ,ESTHER
  • ,FHS
  • ,FINCAVAS
  • ,GCKD
  • ,Generation_R
  • ,JHS
  • ,KORA
  • ,LIFE-Adult
  • ,LIFE-Child
  • ,LifeLines
  • ,Living-Biobank
  • ,MESA
  • ,MICROS
  • ,MyCode
  • ,NEO
  • ,PIVUS
  • ,POPGEN
  • ,PREVEND
  • ,RS
  • ,SCES
  • ,SHIP
  • ,SIMES
  • ,SINDI
  • ,SKIPOGH
  • ,SORBS
  • ,SP2
  • ,UKB
  • ,ULSAM
  • ,deCODE
GWAS Catalog: GCST008790
Europe PMC: 31511532
1,442 individualsHispanic or Latin American38 cohorts
  • AA-DHS
  • ,ADVANCE
  • ,AGES
  • ,AMISH
  • ,ARIC
  • ,BioVU
  • ,CHRIS
  • ,CHS
  • ,DIACORE
  • ,ESTHER
  • ,FHS
  • ,FINCAVAS
  • ,GCKD
  • ,Generation_R
  • ,JHS
  • ,KORA
  • ,LIFE-Adult
  • ,LIFE-Child
  • ,LifeLines
  • ,Living-Biobank
  • ,MESA
  • ,MICROS
  • ,MyCode
  • ,NEO
  • ,PIVUS
  • ,POPGEN
  • ,PREVEND
  • ,RS
  • ,SCES
  • ,SHIP
  • ,SIMES
  • ,SINDI
  • ,SKIPOGH
  • ,SORBS
  • ,SP2
  • ,UKB
  • ,ULSAM
  • ,deCODE
Showing 1 to 5 of 5 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM002203PSS001079|
European Ancestry|
232,751 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Microalbuminuria——Odds Ratio (OR, top 25% vs bottom 25%): 1.69 [1.64, 1.75]
Beta (top 25% vs bottom 25%): 0.527 (0.018)		——
PPM002204PSS001074|
European Ancestry|
182,870 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Disorders of lipid metabolismOR: 1.58
β: 0.46 (0.07)		——PCs(1-10), sex—
PPM002205PSS001074|
European Ancestry|
182,870 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: HyperlipidemiaOR: 1.58
β: 0.46 (0.07)		——PCs(1-10), sex—
PPM002206PSS001074|
European Ancestry|
182,870 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Mixed hyperlipidemiaOR: 1.69
β: 0.53 (0.11)		——PCs(1-10), sex—
PPM002207PSS001078|
European Ancestry|
121,142 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Fuchs' dystrophyOR: 6.68 [3.06, 14.59]
β: 1.9 (0.4)		——PCs(1-10), sex—
PPM002208PSS001073|
European Ancestry|
182,884 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: HypertensionOR: 1.38
β: 0.32 (0.07)		——PCs(1-10), sex—
PPM002209PSS001073|
European Ancestry|
182,884 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Essential hypertensionOR: 1.37
β: 0.32 (0.07)		——PCs(1-10), sex—
PPM002210PSS001077|
European Ancestry|
186,343 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: ProteinuriaOR: 2.7 [1.76, 4.14]
β: 0.99 (0.22)		——PCs(1-10), sex—
PPM002211PSS001075|
European Ancestry|
188,088 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: GoutOR: 1.6
β: 0.47 (0.1)		——PCs(1-10), sex—
PPM002212PSS001075|
European Ancestry|
188,088 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Gout and other crystal arthropathiesOR: 1.58
β: 0.46 (0.1)		——PCs(1-10), sex—
PPM002213PSS001076|
European Ancestry|
73,407 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: HypercholesterolemiaOR: 1.47
β: 0.39 (0.09)		——PCs(1-10), sex—
PPM021122PSS011530|
African Ancestry|
288 individuals
PGP000613 |
Rashkin SR et al. Br J Haematol (2021)
|Ext.		Reported Trait: Time to albuminuria in children with sickle cell anaemiaHR: 1.49
β: 0.4 (0.17)		——Sex, hydroxycarbamide duration, chronic transfusion duration, first 5 PCsOnly 45 of 59 SNPs were used for score calculation based on MAF > 0.05
PPM021123PSS011530|
African Ancestry|
288 individuals
PGP000613 |
Rashkin SR et al. Br J Haematol (2021)
|Ext.		Reported Trait: Time to albuminuria in children with sickle cell anaemiaHR: 1.46
β: 0.38 (0.16)		——Sex, hydroxycarbamide duration, chronic transfusion duration, first 5 PCs, known sickle cell anaemia...  chronic kidney disease risk factors (α-thalessemia allele -α deletion, APOL1, BCL11A SNP rs1427407, HMOX1 SNP rs743811)Show moreOnly 45 of 59 SNPs were used for score calculation based on MAF > 0.05
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS001073Cases were individuals with hypertension. Of the 136,370 cases, 136,053 had essential hypertension.—
[
  • 136,370 cases
  • , 46,514 controls
]
—European—MVP—
PSS001074Cases were individuals with disorders of lipid metabolism. Of the 141,461 cases, 141,331 had hyperli... pidemia and 19,150 had mixed hyperlipidemia.Show more—
[
  • 141,461 cases
  • , 41,409 controls
]
—European—MVP—
PSS001075Cases were individuals with gout and other crystal arthropathies. Of the 15,484 cases, 15,011 specif... ically, had gout.Show more—
[
  • 15,484 cases
  • , 172,524 controls
]
—European—MVP—
PSS001076Cases were individuals with hypercholesterolemia.—
[
  • 31,998 cases
  • , 41,409 controls
]
—European—MVP—
PSS001077Cases were individuals with proteinuria.—
[
  • 3,122 cases
  • , 183,221 controls
]
—European—MVP—
PSS001078Cases were individuals with Fuchs' disease.—
[
  • 874 cases
  • , 120,268 controls
]
—European—MVP—
PSS001079Cases were individuals with microalbuminuria (MA). MA was defined by a urinary albumin to creatinine...  ratio (UACR) > 30 mg/g.Show more—
[
  • 30,014 cases
  • , 202,737 controls
]
—European—UKBPossible sample overlap (up to 41%) between this dataset and the dataset used to source GRS_UACR.
PSS011530Albuminuria was defined by a urine albumin to creatinine ratio (UCAR) of > 30mg/g. Time to album... inuria was defined as the age at first instance of UACR > 30mg/g during follow-up.Show moreMean = 3.54 years
Sd = 3.02 years
[
  • 60 cases
  • , 228 controls
]
,
52.08 % Male samples
Mean = 8.1 years
Sd = 3.7 years		African American or Afro-Caribbean—SCCRIP—
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