Predicted Trait | |
Reported Trait | Urinary albumin to creatinine ratio |
Mapped Trait(s) | urinary albumin to creatinine ratio (EFO_0007778) |
Score Construction | |
PGS Name | GRS_UACR |
Development Method | |
Name | Genome-wide significant variants |
Parameters | P < 5e-8 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 59 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000206 |
Citation (link to publication) | Teumer A et al. Nat Commun (2019) |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
---|---|---|---|
GWAS Catalog: GCST008790 Europe PMC: 31511532 | 547,361 individuals | European | 38 cohorts
|
GWAS Catalog: GCST008790 Europe PMC: 31511532 | 6,795 individuals | African American or Afro-Caribbean | 38 cohorts
|
GWAS Catalog: GCST008790 Europe PMC: 31511532 | 6,324 individuals | East Asian | 38 cohorts
|
GWAS Catalog: GCST008790 Europe PMC: 31511532 | 2,335 individuals | South Asian | 38 cohorts
|
GWAS Catalog: GCST008790 Europe PMC: 31511532 | 1,442 individuals | Hispanic or Latin American | 38 cohorts
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM002203 | PSS001079| European Ancestry| 232,751 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Microalbuminuria | — | — | Odds Ratio (OR, top 25% vs bottom 25%): 1.69 [1.64, 1.75] Beta (top 25% vs bottom 25%): 0.527 (0.018) | — | — |
PPM002204 | PSS001074| European Ancestry| 182,870 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Disorders of lipid metabolism | OR: 1.58 β: 0.46 (0.07) | — | — | PCs(1-10), sex | — |
PPM002205 | PSS001074| European Ancestry| 182,870 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Hyperlipidemia | OR: 1.58 β: 0.46 (0.07) | — | — | PCs(1-10), sex | — |
PPM002206 | PSS001074| European Ancestry| 182,870 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Mixed hyperlipidemia | OR: 1.69 β: 0.53 (0.11) | — | — | PCs(1-10), sex | — |
PPM002207 | PSS001078| European Ancestry| 121,142 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Fuchs' dystrophy | OR: 6.68 [3.06, 14.59] β: 1.9 (0.4) | — | — | PCs(1-10), sex | — |
PPM002208 | PSS001073| European Ancestry| 182,884 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Hypertension | OR: 1.38 β: 0.32 (0.07) | — | — | PCs(1-10), sex | — |
PPM002209 | PSS001073| European Ancestry| 182,884 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Essential hypertension | OR: 1.37 β: 0.32 (0.07) | — | — | PCs(1-10), sex | — |
PPM002210 | PSS001077| European Ancestry| 186,343 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Proteinuria | OR: 2.7 [1.76, 4.14] β: 0.99 (0.22) | — | — | PCs(1-10), sex | — |
PPM002211 | PSS001075| European Ancestry| 188,088 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Gout | OR: 1.6 β: 0.47 (0.1) | — | — | PCs(1-10), sex | — |
PPM002212 | PSS001075| European Ancestry| 188,088 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Gout and other crystal arthropathies | OR: 1.58 β: 0.46 (0.1) | — | — | PCs(1-10), sex | — |
PPM002213 | PSS001076| European Ancestry| 73,407 individuals | PGP000206 | Teumer A et al. Nat Commun (2019) | Reported Trait: Hypercholesterolemia | OR: 1.47 β: 0.39 (0.09) | — | — | PCs(1-10), sex | — |
PPM021122 | PSS011530| African Ancestry| 288 individuals | PGP000613 | Rashkin SR et al. Br J Haematol (2021) |Ext. | Reported Trait: Time to albuminuria in children with sickle cell anaemia | HR: 1.49 β: 0.4 (0.17) | — | — | Sex, hydroxycarbamide duration, chronic transfusion duration, first 5 PCs | Only 45 of 59 SNPs were used for score calculation based on MAF > 0.05 |
PPM021123 | PSS011530| African Ancestry| 288 individuals | PGP000613 | Rashkin SR et al. Br J Haematol (2021) |Ext. | Reported Trait: Time to albuminuria in children with sickle cell anaemia | HR: 1.46 β: 0.38 (0.16) | — | — | Sex, hydroxycarbamide duration, chronic transfusion duration, first 5 PCs, known sickle cell anaemia... chronic kidney disease risk factors (α-thalessemia allele -α deletion, APOL1, BCL11A SNP rs1427407, HMOX1 SNP rs743811)Show more | Only 45 of 59 SNPs were used for score calculation based on MAF > 0.05 |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
---|---|---|---|---|---|---|---|---|
PSS001073 | Cases were individuals with hypertension. Of the 136,370 cases, 136,053 had essential hypertension. | — | [
| — | European | — | MVP | — |
PSS001074 | Cases were individuals with disorders of lipid metabolism. Of the 141,461 cases, 141,331 had hyperli... pidemia and 19,150 had mixed hyperlipidemia.Show more | — | [
| — | European | — | MVP | — |
PSS001075 | Cases were individuals with gout and other crystal arthropathies. Of the 15,484 cases, 15,011 specif... ically, had gout.Show more | — | [
| — | European | — | MVP | — |
PSS001076 | Cases were individuals with hypercholesterolemia. | — | [
| — | European | — | MVP | — |
PSS001077 | Cases were individuals with proteinuria. | — | [
| — | European | — | MVP | — |
PSS001078 | Cases were individuals with Fuchs' disease. | — | [
| — | European | — | MVP | — |
PSS001079 | Cases were individuals with microalbuminuria (MA). MA was defined by a urinary albumin to creatinine... ratio (UACR) > 30 mg/g.Show more | — | [
| — | European | — | UKB | Possible sample overlap (up to 41%) between this dataset and the dataset used to source GRS_UACR. |
PSS011530 | Albuminuria was defined by a urine albumin to creatinine ratio (UCAR) of > 30mg/g. Time to album... inuria was defined as the age at first instance of UACR > 30mg/g during follow-up.Show more | Mean = 3.54 years Sd = 3.02 years | [ ,
52.08 % Male samples | Mean = 8.1 years Sd = 3.7 years | African American or Afro-Caribbean | — | SCCRIP | — |