Predicted Trait | |
Reported Trait | Prostate cancer |
Mapped Trait(s) | prostate carcinoma (EFO_0001663) |
Score Construction | |
PGS Name | PRS4_PC |
Development Method | |
Name | Clumping of genome-wide significant SNPs |
Parameters | R^2 < 0.001 |
Variants | |
Original Genome Build | NR |
Number of Variants | 4 |
Effect Weight Type | log(OR) |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000224 |
Citation (link to publication) | Oh JJ et al. Front Oncol (2020) |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | East Asian: 100% 3,178 individuals (100%) |
PGS Evaluation | East Asian: 100% 1 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
— | [ ,
100.0 % Male samples |
East Asian (Korean) |
KARE |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM002516 | PSS001135| East Asian Ancestry| 638 individuals |
PGP000224 | Oh JJ et al. Front Oncol (2020) |
Reported Trait: Prostate cancer | — | AUROC: 0.637 | Odds Ratio (OR, top 25% vs bottom 25%): 4.2 [2.32, 7.98] | Age | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS001135 | Cases are individuals with prostate cancer. 80% of the cases are diagnosed with prostate cancer with a gleason score of ≥ 7. | — | [ ,
100.0 % Male samples |
— | East Asian (Korean) |
— | NR | — |