PGS Publication: PGP000224

Publication Information (EuropePMC)
Title Evaluation of Polygenic Risk Scores for Prediction of Prostate Cancer in Korean Men.
PubMed ID 33194723(Europe PMC)
doi 10.3389/fonc.2020.583625
Publication Date Oct. 22, 2020
Journal Front Oncol
Author(s) Oh JJ, Kim E, Woo E, Song SH, Kim JK, Lee H, Lee S, Hong SK, Byun SS.
Released in PGS Catalog: Aug. 26, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000878
(PRS4_PC)
 PGP000224 |
Oh JJ et al. Front Oncol (2020)
 Prostate cancer prostate carcinoma 4
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000878/ScoringFiles/PGS000878.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002516 PGS000878
(PRS4_PC)
 PSS001135|
East Asian Ancestry|
638 individuals
 PGP000224 |
Oh JJ et al. Front Oncol (2020)
 Reported Trait: Prostate cancer — AUROC: 0.637 Odds Ratio (OR, top 25% vs bottom 25%): 4.2 [2.32, 7.98] Age —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001135 Cases are individuals with prostate cancer. 80% of the cases are diagnosed with prostate cancer with a gleason score of ≥ 7. —
[
  • 514 cases
  • , 124 controls
]
,
100.0 % Male samples
 — East Asian
(Korean)		 — NR —