Polygenic Score (PGS) ID: PGS000899

Predicted Trait
Reported Trait Coronary heart disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Sept. 17, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS176_CHD
Development Method
Name Two sets of SNPS: (1) genome-wide significant SNPs, (2) SNPs in low linkage disequilibrium
Parameters (1) P < 5e-8, (2) r^2 < 0.2
Variants
Original Genome Build GRCh37
Number of Variants 176
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000232
Citation (link to publication) Feitosa MF et al. Circ Genom Precis Med (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 63.8%
European: 17%
Multi-ancestry (including European): 15%
  • European
  • South Asian
South Asian: 1.9%
East Asian: 1.3%
African: 0.6%
Hispanic or Latin American: 0.2%
Greater Middle Eastern: 0.1%
1,716,874 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Europe PMC: 28530674
[
  • 14,267 cases
  • , 16,167 controls
]
EuropeanCCHS, CGPS, CIHDS, EPIC
Europe PMC: 28530674
[
  • 4,129 cases
  • , 6,369 controls
]
,
62.83 % Male samples
East AsianTaiChi
Europe PMC: 28530674
[
  • 3,950 cases
  • , 3,581 controls
]
South AsianBRAVE, PROMIS
Europe PMC: 28530674
[
  • 2,100 cases
  • , 5,746 controls
]
African American or Afro-CaribbeanARIC, MIGen, WHI
Europe PMC: 28530674
[
  • 63,746 cases
  • , 130,681 controls
]
European, South AsianCARDIoGRAMplusC4D
GWAS Catalog: GCST003116
Europe PMC: 26343387
3,139 individualsAfrican American or Afro-Caribbean41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
4,095 individualsHispanic or Latin American41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
11,323 individualsEast Asian41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
25,557 individualsSouth Asian41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
141,217 individualsEuropean41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
2,268 individualsGreater Middle Eastern (Middle Eastern, North African or Persian)40 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST004787
Europe PMC: 28714975
63,731 individualsEuropean, NRNR
GWAS Catalog: GCST005194
Europe PMC: 29212778
296,525 individualsNRUKB
GWAS Catalog: GCST005195
Europe PMC: 29212778
547,261 individualsNot reportedCARDIoGRAMplusC4D, UKB
GWAS Catalog: GCST005196
Europe PMC: 29212778
250,736 individualsNot reportedCARDIoGRAMplusC4D
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM002640PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onsetHR: 1.6 [1.33, 1.92]——Age, sex, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipopr... otein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.Show more—
PPM002641PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onsetHR: 1.35 [1.26, 1.45]——Age, sex, study, type II diabetes, hypertension, high density lipoprotein cholesterol, low density l... ipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.Show more—
PPM002642PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onsetHR: 1.7 [1.41, 2.05]——Age, sex, study, PRS*sex, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high densi... ty lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.Show more—
PPM002643PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onsetHR: 1.75 [1.16, 2.65]——Age, sex, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipopr... otein cholesterol, low density lipoprotein cholesterol, menopause, waist circumference, current cigarette smoking, current alcohol drinking.Show more—
PPM002644PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset (males)HR: 1.57 [1.28, 1.92]——Age, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein...  cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.Show more—
PPM002645PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset (males)HR: 1.42 [1.3, 1.54]——Age, study, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipopr... otein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.Show more—
PPM002646PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset (females)HR: 1.76 [1.16, 2.68]——Age, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein...  cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.Show more—
PPM002647PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset (females)HR: 1.18 [1.04, 1.34]——Age, study, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipopr... otein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.Show more—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS001168Cases were individulas with prevalent CHD was obtained by self-report of a coronary bypass, myocardi... al infarction, or any of the following: coronary angioplasty, balloon angioplasty, atherectomy, stent, percutaneous transluminal coronary angioplasty, or percutaneous coronary intervention. CHD information was similarly obtained in LLFS and FamHS; however, CHD was only validated by hospital records in FamHS. Age-at-onset was defined as the individual's age at the first report of CHD.Show more—
[
  • 950 cases
  • , 6,453 controls
]
,
46.25 % Male samples
Mean = 60.6 yearsEuropean—FamHS, LLFS—
Showing 1 to 1 of 1 rows