Polygenic Score (PGS) ID: PGS000900

Predicted Trait
Reported Trait Systolic blood pressure (female)
Mapped Trait(s)
Released in PGS Catalog: Sept. 17, 2021
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Score Details

Score Construction
PGS Name PRS_SBP_f
Development Method
Name PRS-CS
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,098,015
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000233
Citation (link to publication) Kauko A et al. Hypertension (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
194,174 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Neale Lab UKB GWAS (round 2)
 194,174 individuals,
0.0 % Male samples
 European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002648 PSS001169|
European Ancestry|
123,579 individuals
 PGP000233 |
Kauko A et al. Hypertension (2021)
 Reported Trait: Hypertension HR: 1.42 [1.4, 1.44] — Hazard Ratio (HR, top 2.5% vs middle 60%): 2.12 [1.99, 2.25] Age as timescale, collection year, genotyping batch, PCs(1-10) —
PPM002650 PSS001169|
European Ancestry|
123,579 individuals
 PGP000233 |
Kauko A et al. Hypertension (2021)
 Reported Trait: Early-onset hypertension (< 55 years) HR: 1.56 [1.53, 1.58] — Hazard Ratio (HR, top 2.5% vs middle 60%): 2.51 [2.32, 2.72] Age as timescale, collection year, genotyping batch, PCs(1-10) —
PPM002652 PSS001169|
European Ancestry|
123,579 individuals
 PGP000233 |
Kauko A et al. Hypertension (2021)
 Reported Trait: Late-onset hypertension (> 55 years) HR: 1.31 [1.28, 1.33] — Hazard Ratio (HR, top 2.5% vs middle 60%): 1.66 [1.5, 1.84] Age as timescale, collection year, genotyping batch, PCs(1-10) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001169 Cases were individuals with hypertension. Of the 27,804 cases, 13,279 had early-onset hypertension (age of onset < 55 years) whilst 14,525 had late-onset hypertension (age of onset ≥ 55 years). —
[
  • 27,804 cases
  • , 95,775 controls
]
,
0.0 % Male samples
 — European
(Finnish)		 — FinnGen —