| Predicted Trait | |
| Reported Trait | PR interval |
| Mapped Trait(s) | PR interval (EFO_0004462) |
| Score Construction | |
| PGS Name | PRS582_PR |
| Development Method | |
| Name | Clumping and Thresholding (C+T) |
| Parameters | r^2 = 0.1 in a 250kb region, p = 5e-8, imputation quality > 0.6 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 582 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000236 |
| Citation (link to publication) | Ntalla I et al. Nat Commun (2020) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 271,570 individuals (100%) |
| PGS Evaluation | European: 100% 8 Sample Sets |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
GWAS Catalog: GCST010320 Europe PMC: 32439900 | 271,570 individuals | European | 34 cohorts
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM002666 | PSS001175| European Ancestry| 309,269 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Atrial fibrillation | OR: 0.95 β: -0.047 (0.009) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002667 | PSS001178| European Ancestry| 290,252 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Distal conduction disease | OR: 1.11 β: 0.103 (0.019) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002668 | PSS001176| European Ancestry| 309,041 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Atrioventricular preexcitation | OR: 0.85 β: -0.168 (0.057) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002669 | PSS001179| European Ancestry| 309,241 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Implantable cardioverter defibrillator | OR: 1.09 β: 0.086 (0.04) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002670 | PSS001180| European Ancestry| 309,246 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Mitral valve prolapse | OR: 1.1 β: 0.093 (0.044) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002671 | PSS001181| European Ancestry| 305,471 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Non-ischemic cardiomyopathy | OR: 0.95 β: -0.051 (0.024) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002672 | PSS001182| European Ancestry| 309,270 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Pacemaker | OR: 1.06 β: 0.062 (0.016) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002673 | PSS001183| European Ancestry| 309,255 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Valve disease | OR: 1.03 β: 0.03 (0.013) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS001175 | Cases were individuals with atrial fibrillation. Disease status was ascertained based on data from b... aseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001176 | Cases were individuals with atrioventricular preexcitation. Disease status was ascertained based on ... data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001178 | Cases were individuals with distal conduction disease. Disease status was ascertained based on data ... from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001179 | Cases were individuals with implantable cardioverter defibrillators. Disease status was ascertained ... based on data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001180 | Cases were individuals with mitral valve prolapse. Disease status was ascertained based on data from... baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001181 | Cases were individuals with non-ischemic cardiomyopathy. Disease status was ascertained based on dat... a from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001182 | Cases were individuals with a pacemaker. Disease status was ascertained based on data from baseline ... interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001183 | Cases were individuals with valve disease. Disease status was ascertained based on data from baselin... e interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |